Tìm theo
oportuzumab monatox
Các tên gọi khác (1) :
  • VB4-845
Thuốc Gốc
Biotech
VB4-845 is studied in the treatment of certain types of head and neck cancer. VB4-845 is made by linking a monoclonal antibody fragment to a toxic protein that may kill cancer cells. VB4-845 is a fusion protein containing humanized scFv specific for the epithelial cell adhesion molecule, Ep-CAM, a tumor cell-associated target highly expressed on carcinoma cells of epithelial origin and a truncated portion of Pseudomonas exotoxin A.
Cơ Chế Tác Dụng : VB4-845 is studied in the treatment of certain types of head and neck cancer. VB4-845 is made by linking a monoclonal antibody fragment to a toxic protein that may kill cancer cells. VB4-845 is a fusion protein containing humanized scFv specific for the epithelial cell adhesion molecule, Ep-CAM, a tumor cell-associated target highly expressed on carcinoma cells of epithelial origin and a truncated portion of Pseudomonas exotoxin A. VB4-845 binds to EpCAM (a protein on the surface of epithelial cells and some types of cancer cells). Also called anti-EpCAM-Pseudomonas-exotoxin fusion protein and Proxinium. It targets and kills Ep-CAM-positive tumors by apoptosis.
Chỉ Định : Investigated for use/treatment in bladder cancer and head and neck cancer.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Proxinium
  • Công ty :
    Sản phẩm biệt dược : Vicinium
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05319
Wikipedia
http://en.wikipedia.org/wiki/Oportuzumab_monatox
... loading
... loading