Tìm theo
ONO-2506
Thuốc Gốc
Small Molecule
CTHH: C11H22O2
PTK: 186.2912
ONO-2506 is an enantiomeric, three carbon atom homolog of valproic acid under development by ONO Pharmaceutical for the potential treatment of stroke, as well as Alzheimer's and Parkinson's disease.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C11H22O2
Phân tử khối
186.2912
Monoisotopic mass
186.161979948
InChI
InChI=1S/C11H22O2/c1-3-5-6-7-9-10(8-4-2)11(12)13/h10H,3-9H2,1-2H3,(H,12,13)/t10-/m1/s1
InChI Key
InChIKey=YCYMCMYLORLIJX-SNVBAGLBSA-N
IUPAC Name
(2R)-2-propyloctanoic acid
Traditional IUPAC Name
arundic acid
SMILES
CCCCCC[C@@H](CCC)C(O)=O
Độ hòa tan
9.19e-02 g/l
logP
4.13
logS
-3.3
pKa (strongest acidic)
5.24
PSA
37.3 Å2
Refractivity
54.05 m3·mol-1
Polarizability
23.23 Å3
Rotatable Bond Count
8
H Bond Acceptor Count
2
H Bond Donor Count
1
Physiological Charge
-1
Number of Rings
0
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Cơ Chế Tác Dụng : ONO-2506 is an enantiomeric, three carbon atom homolog of valproic acid under development by ONO Pharmaceutical for the potential treatment of stroke, as well as Alzheimer's and Parkinson's disease. ONO-256 is a neuroprotective because of its actions on glia cells. It has inhibitory effects on the synthesis of a calcium-binding protein S100B. ONO-2506 is undergoing clinical trials for the treatment of patients with stroke and Alzheimer's disease.
Chỉ Định : Investigated for use/treatment in cerebral ischemia.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Proglia
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05343
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=208925
ChemSpider
http://www.chemspider.com/Chemical-Structure.181021.html
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