Tìm theo
Ocriplasmin
ophthalmics
Thuốc Gốc
Biotech
CAS: 1048016-9-6
CTHH: C1214H1890N338O348S14
PTK: 27.25 kDa
Ocriplasmin is a recombinant truncated form of human plasmin with a molecular weight of 27.2 kDa produced by recombinant DNA technology in a Pichia pastoris expression system. Ocriplasmin is a protein made up of 249 amino acids and has two peptide chains. Agent for pharmacologic vitreolysis; thrombolytic agent. FDA approved in October 17, 2012.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C1214H1890N338O348S14
Phân tử khối
27.25 kDa
Cơ Chế Tác Dụng : Ocriplasmin is a recombinant truncated form of human plasmin with a molecular weight of 27.2 kDa produced by recombinant DNA technology in a Pichia pastoris expression system. Ocriplasmin is a protein made up of 249 amino acids and has two peptide chains. Agent for pharmacologic vitreolysis; thrombolytic agent. FDA approved in October 17, 2012. Ocriplasmin has proteolytic activity against protein components of the vitreous body and the vitreoretinal interface (VRI) (e.g. laminin, fibronectin and collagen), thereby dissolving the protein matrix responsible for the vitreomacular adhesion (VMA).
Dược Động Học :
▧ Absorption :
Because of the small dose administered (0.125 mg), ocriplasmin is not expected to be in the systemic circulation following injection. Within 30 minutes after injection, levels of ocriplasmin in the vitreous are 12 mcg/mL. 24 hours after injection, levels in the virtreous are 0.5 mcg/mL
▧ Metabolism :
Ocriplasmin is quickly inactivated by protease inhibitor α2-antiplasmin or α2-macroglobulin.
Độc Tính : The most commonly reported reactions (≥ 5%) in patients treated with ocriplasmin were vitreous floaters, conjunctival hemorrhage, eye pain, photopsia, blurred vision, macular hole, reduced visual acuity, visual impairment, and retinal edema.
Chỉ Định : Ocriplasmin is a proteolytic enzyme indicated for the treatment for symptomatic vitreomacular adhesion.
Liều Lượng & Cách Dùng : Solution - Intraocular - 0.5 mg/0.2 mL
Dữ Kiện Thương Mại
Nhà Sản Xuất
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB08888
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D09646
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/24856-001-00
Wikipedia
http://en.wikipedia.org/wiki/Ocriplasmin
RxList
http://www.rxlist.com/jetrea-drug.htm
Drugs.com
http://www.drugs.com/jetrea.html
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