Tìm theo
Nonoxynol-9
Các tên gọi khác (9 ) :
  • 26-(Nonylphenoxy)-3,6,9,12,15,18,21,24-octaoxahexacosan-1-ol
  • Nonaethylene glycol mono(nonylphenyl) ether
  • Nonaethylene glycol nonylphenyl ether
  • Nonoxynol 9
  • Nonylphenol octa(oxyethylene) ethanol
  • P-Nonylphenyl polyethylene glycol ether
  • PEG-9 nonyl phenyl ether
  • Polyoxyethylene (9) nonyl phenyl ether
  • Tergitol NP9
contraceptive agents
Thuốc Gốc
Small Molecule
CAS: 26571-11-9
CTHH: C33H60O10
PTK: 616.8235
Nonoxynol-9 (N-9) is a typical surfactant used as a vaginal spermicide. Spermicides are locally acting non-hormonal contraceptives. When present in the vagina during intercourse, they immobilize/inactivate/damage and/or kill sperms without eliciting systemic effects. N-9 has been in use for more than 30 years as an over-the-counter (OTC) drug in creams, gels, foams and condom lubricants. It is the most commonly used spermicidal contraceptive in the UK and the USA. In several European countries, spermicides are no longer on the market.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C33H60O10
Phân tử khối
616.8235
Monoisotopic mass
616.41864814
InChI
InChI=1S/C33H60O10/c1-2-3-4-5-6-7-8-9-32-10-12-33(13-11-32)43-31-30-42-29-28-41-27-26-40-25-24-39-23-22-38-21-20-37-19-18-36-17-16-35-15-14-34/h10-13,34H,2-9,14-31H2,1H3
InChI Key
InChIKey=FBWNMEQMRUMQSO-UHFFFAOYSA-N
IUPAC Name
1-(4-nonylphenyl)-1,4,7,10,13,16,19,22,25-nonaoxaheptacosan-27-ol
Traditional IUPAC Name
nonoxynol 9
SMILES
CCCCCCCCCC1=CC=C(OCCOCCOCCOCCOCCOCCOCCOCCOCCO)C=C1
Độ hòa tan
2.14e-04 g/l
logP
4.82
logS
-6.5
pKa (strongest acidic)
15.12
pKa (Strongest Basic)
-2.7
PSA
103.3 Å2
Refractivity
169.01 m3·mol-1
Polarizability
77.07 Å3
Rotatable Bond Count
35
H Bond Acceptor Count
10
H Bond Donor Count
1
Physiological Charge
0
Number of Rings
1
Bioavailability
0
Cơ Chế Tác Dụng : Nonoxynol-9 (N-9) is a typical surfactant used as a vaginal spermicide. Spermicides are locally acting non-hormonal contraceptives. When present in the vagina during intercourse, they immobilize/inactivate/damage and/or kill sperms without eliciting systemic effects. N-9 has been in use for more than 30 years as an over-the-counter (OTC) drug in creams, gels, foams and condom lubricants. It is the most commonly used spermicidal contraceptive in the UK and the USA. In several European countries, spermicides are no longer on the market. Nonoxynol-9 interacts with the lipids in the membranes of the acrosome and the midpiece of the sperm. The sperm membranes are lysed; the acrosome, neck and midpiece of the spermatozoa are loosened and then detached which results in their immobilization and death.
Độc Tính : The major drawback of nonoxynol-9 is its detergent-type action on epithelial cells and the normal vaginal flora. Detergent-type spermicides alter the vaginal flora, possibly leading to an increased risk of opportunistic infections. These are known to enhance the susceptibility of the epithelium of the lower genital tract to HIV and human papillomavirus infection. N-9 can cause vaginal irritation and allergic vaginitis as well as genital irritation in male partners.
Chỉ Định : Nonoxynol 9 is a surfactant spermicide used for contraception in spermicidal creams, jellies, foams, gel, and lubricants. It is also used in conjuction with other methods of contraception, including condoms, cervical caps and diaphragms.
Dữ Kiện Thương Mại
Nhà Sản Xuất
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB06804
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=72385
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=99443296
ChemSpider
http://www.chemspider.com/Chemical-Structure.65319.html
Wikipedia
http://en.wikipedia.org/wiki/Nonoxynol-9
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