Tìm theo
Nomifensine
Các tên gọi khác (12 ) :
  • (+-)-nomifensin
  • (+-)-nomifensine
  • (+)-nomifensine
  • (+)-nomiphensine
  • (R)-1,2,3,4-Tetrahydro-2-methyl-4-phenyl-8-isoquinolinamine
  • 2-Methyl-4-phenyl-1,2,3,4-tetrahydro-8-isoquinolinamine
  • 8-Amino-1,2,3,4-tetrahydro-2-methyl-4-phenylisochinolin
  • 8-Amino-1,2,3,4-tetrahydro-2-methyl-4-phenylisoquinoline
  • 8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline
  • Nomifensin
  • Nomifensina
  • Nomifensinum
dopamine uptake inhibitors
Thuốc Gốc
Small Molecule
CAS: 24526-64-5
ATC: N06AX04
CTHH: C16H18N2
PTK: 238.3275
Nomifensine, formerly marketed as Merital capsules, was associated with an increased incidence of hemolytic anemia. The approved application holder removed Merital capsules from the market on January 23, 1986. FDA published a notice of its determination that Merital capsules were removed from the market for safety reasons (see the Federal Register of June 17, 1986 (51 FR 21981)). Approval of the NDA for Merital capsules was withdrawn on March 20, 1992 (see the Federal Register of March 20, 1992 (57 FR 9729)). Also withdrawn from the Canadian and UK markets.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C16H18N2
Phân tử khối
238.3275
Monoisotopic mass
238.146998586
InChI
InChI=1S/C16H18N2/c1-18-10-14(12-6-3-2-4-7-12)13-8-5-9-16(17)15(13)11-18/h2-9,14H,10-11,17H2,1H3
InChI Key
InChIKey=XXPANQJNYNUNES-UHFFFAOYSA-N
IUPAC Name
2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine
Traditional IUPAC Name
nomifensine
SMILES
CN1CC(C2=CC=CC=C2)C2=C(C1)C(N)=CC=C2
Độ tan chảy
180 °C
Độ hòa tan
3.18e-01 g/l
logP
2.62
logS
-2.9
pKa (Strongest Basic)
8.88
PSA
29.26 Å2
Refractivity
77.18 m3·mol-1
Polarizability
27.56 Å3
Rotatable Bond Count
1
H Bond Acceptor Count
2
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Nomifensine is a dopamine reuptake inhibitor test-marketed in the United States by Hoechst AG (now Novartis) that increases the amount of synaptic dopamine available to receptors by blocking dopamine's re-uptake transporter. Nomifensine is now mainly used in scientific research, particularly in studies involving dopamine release in response to addiction.
Độc Tính : A likely cause of nomifensine toxicity is the aromatic amine group, as compounds containing this chemical substructure are notorious for producing toxic metabolites.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Linamiphen
  • Công ty :
    Sản phẩm biệt dược : Merital
  • Công ty :
    Sản phẩm biệt dược : Nomifenison
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB04821
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=4528
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505804
ChemSpider
http://www.chemspider.com/Chemical-Structure.4371.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50005548
Wikipedia
http://en.wikipedia.org/wiki/Nomifensine
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