Tìm theo
Nitroxoline
Các tên gọi khác (9 ) :
  • 5-Nitro-8-hydroxyquinoline
  • 5-Nitro-8-oxyquinoline
  • 5-Nitro-8-quinolinol
  • 5-Nitrox
  • 5-NOK
  • 5NOK
  • 8-Hydroxy-5-nitroquinoline
  • Nitroxolina
  • Nitroxolinum
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 4008-48-4
ATC: J01XX07
CTHH: C9H6N2O3
PTK: 190.1555
Nitroxoline is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections. It is a fluorquinolone that is active against bacterial gyrases.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C9H6N2O3
Phân tử khối
190.1555
Monoisotopic mass
190.037842068
InChI
InChI=1S/C9H6N2O3/c12-8-4-3-7(11(13)14)6-2-1-5-10-9(6)8/h1-5,12H
InChI Key
InChIKey=RJIWZDNTCBHXAL-UHFFFAOYSA-N
IUPAC Name
5-nitroquinolin-8-ol
Traditional IUPAC Name
nitroxoline
SMILES
OC1=C2N=CC=CC2=C(C=C1)[N+]([O-])=O
Độ tan chảy
180 °C
Độ hòa tan
2.73e+00 g/l
logP
1.99
logS
-1.8
pKa (strongest acidic)
6.88
pKa (Strongest Basic)
2.08
PSA
78.94 Å2
Refractivity
49.28 m3·mol-1
Polarizability
17.16 Å3
Rotatable Bond Count
1
H Bond Acceptor Count
4
H Bond Donor Count
1
Physiological Charge
-1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Cơ Chế Tác Dụng : Nitroxoline is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections. It is a fluorquinolone that is active against bacterial gyrases. This drug may also have antitumor activity by inhibition of type 2 methionine aminopeptidase (MetAP2) protein which is involved in angiogenesis. Its antibacterial activity may stem from the metal ion complexation vital for bacterial growth.
Chỉ Định : Nitroxoline is an antibiotic agent.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Nitroxoline
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01422
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=19910
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505497
ChemSpider
http://www.chemspider.com/Chemical-Structure.18756.html
PharmGKB
http://www.pharmgkb.org/drug/PA164754993
Wikipedia
http://en.wikipedia.org/wiki/Nitroxoline
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