Tìm theo
Nitroprusside
Các tên gọi khác (2) :
  • [Fe(CN)5(NO)](2-)
  • Nitroferricyanide
Thuốc Gốc
Small Molecule
CAS: 15078-28-1
ATC: C02DD01
ĐG : Baxter International Inc. , http://www.baxter.com
CTHH: C5FeN6O
PTK: 215.938
Nitroprusside serves as a source of nitric oxide, a potent peripheral vasodilator that affects both arterioles and venules (venules more than arterioles). Nitroprusside is often administered intravenously to patients who are experiencing a hypertensive emergency. [Wikipedia]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C5FeN6O
Phân tử khối
215.938
Monoisotopic mass
215.948300785
InChI
InChI=1S/5CN.Fe.NO/c5*1-2;;1-2/q;;;;;2*-1
InChI Key
InChIKey=ASPOIVQEUUCDQT-UHFFFAOYSA-N
IUPAC Name
pentacyano(nitroso)irondiuide
Traditional IUPAC Name
nitroprusside
SMILES
O=N[Fe--](C#N)(C#N)(C#N)(C#N)C#N
logP
0.071
pKa (Strongest Basic)
-3.3
PSA
148.38 Å2
Refractivity
39.44 m3·mol-1
Polarizability
16.52 Å3
Rotatable Bond Count
1
H Bond Acceptor Count
6
H Bond Donor Count
0
Physiological Charge
-2
Number of Rings
0
Bioavailability
1
Rule of Five
true
Dược Lực Học : Nitroprusside a powerful vasodilator relaxes the vascular smooth muscle and produce consequent dilatation of peripheral arteries and veins. Other smooth muscle (e.g., uterus, duodenum) is not affected. Sodium nitroprusside is more active on veins than on arteries.
Cơ Chế Tác Dụng : Nitroprusside serves as a source of nitric oxide, a potent peripheral vasodilator that affects both arterioles and venules (venules more than arterioles). Nitroprusside is often administered intravenously to patients who are experiencing a hypertensive emergency. [Wikipedia] One molecule of sodium nitroprusside is metabolized by combination with hemoglobin to produce one molecule of cyanmethemoglobin and four CN- ions; methemoglobin, obtained from hemoglobin, can sequester cyanide as cyanmethemoglobin; thiosulfate reacts with cyanide to produce thiocyanate; thiocyanate is eliminated in the urine; cyanide not otherwise removed binds to cytochromes. Cyanide ion is normally found in serum; it is derived from dietary substrates and from tobacco smoke. Cyanide binds avidly (but reversibly) to ferric ion (Fe+++), most body stores of which are found in erythrocyte methemoglobin (metHgb) and in mitochondrial cytochromes. When CN is infused or generated within the bloodstream, essentially all of it is bound to methemoglobin until intraerythrocytic methemoglobin has been saturated. Once activated to NO, it activates guanylate cyclase in vascular smooth muscle and increases intracellular production of cGMP. cGMP stimulates calcium movement from the cytoplasm to the endoplasmic reticulum and reduces calcium available to bind with calmodulin. This eventually leads to vascular smooth muscle relaxation and vessel dilatation.
Dược Động Học :

▧ Metabolism :
Metabolized by reaction with hemoglobin to produce cyanmethemoglobin and cynide ions
▧ Route of Elimination :
One molecule of sodium nitroprusside is metabolized by combination with hemoglobin to produce one molecule of cyanmethemoglobin and four CN¯ ions, thiosulfate reacts with cyanide to produce thiocyanate, thiocyanate is eliminated in the urine.
▧ Half Life :
Approximately 2 minutes
Độc Tính : Overdosage of nitroprusside can be manifested as excessive hypotension or cyanide toxicity or as thiocyanate toxicity. The acute intravenous mean lethal doses (LD50) of nitroprusside in rabbits, dogs, mice, and rats are 2.8, 5.0, 8.4, and 11.2 mg/kg, respectively.
Chỉ Định : For immediate reduction of blood pressure of patients in hypertensive crises, reduce bleeding during surgery, and for the treatment of acute congestive heart failure
Tương Tác Thuốc :
  • Treprostinil Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Liều Lượng & Cách Dùng : Powder, for solution - Intravenous
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Nipride
  • Công ty :
    Sản phẩm biệt dược : Nitropress
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00325
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=11963622
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508965
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07269
ChemSpider
http://www.chemspider.com/Chemical-Structure.10137785.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0409-3024-01
PharmGKB
http://www.pharmgkb.org/drug/PA451406
Wikipedia
http://en.wikipedia.org/wiki/Nitroprusside
RxList
http://www.rxlist.com/cgi/generic3/nitroprusside.htm
Drugs.com
http://www.drugs.com/mtm/nitroprusside.html
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