Tìm theo
Nitrofural
Các tên gọi khác (5 ) :
  • 5-Nitro-2-furaldehyde semicarbazone
  • Furacilin
  • Furacin
  • Nitrofural
  • Nitrofurazone
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 59-87-0
ATC: P01CC02, S02AA02, S01AX04, D09AA03, B05CA03, D08AF01
ĐG : Gallipot , http://www.gallipot.com
CTHH: C6H6N4O4
PTK: 198.1362
A topical anti-infective agent effective against gram-negative and gram-positive bacteria. It is used for superficial wounds, burns, ulcers, and skin infections. Nitrofurazone has also been administered orally in the treatment of trypanosomiasis. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C6H6N4O4
Phân tử khối
198.1362
Monoisotopic mass
198.0389047
InChI
InChI=1S/C6H6N4O4/c7-6(11)9-8-3-4-1-2-5(14-4)10(12)13/h1-3H,(H3,7,9,11)/b8-3+
InChI Key
InChIKey=IAIWVQXQOWNYOU-FPYGCLRLSA-N
IUPAC Name
[(E)-[(5-nitrofuran-2-yl)methylidene]amino]urea
Traditional IUPAC Name
(E)-[(5-nitrofuran-2-yl)methylidene]aminourea
SMILES
NC(=O)N\N=C\C1=CC=C(O1)[N+]([O-])=O
Độ tan chảy
238 dec °C
Độ hòa tan
210 mg/L (at 25 °C)
logP
0.23
logS
-2.9
pKa (strongest acidic)
11.79
pKa (Strongest Basic)
-2
PSA
126.44 Å2
Refractivity
45.21 m3·mol-1
Polarizability
16.92 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
4
H Bond Donor Count
2
Physiological Charge
0
Number of Rings
1
Bioavailability
1
Rule of Five
true
Ghose Filter
true
pKa
10
Dược Lực Học : Nitrofurazone is a topical antibacterial agent indicated as an adjunctive therapy for second and third degree burns when resistance to other agents is a real or potential problem. Nitrofurazone is also indicated in skin grafting when bacterial contamination may cause graft rejection or donor site infection, especially in hospitals with a history of resistant bacteria.
Cơ Chế Tác Dụng : A topical anti-infective agent effective against gram-negative and gram-positive bacteria. It is used for superficial wounds, burns, ulcers, and skin infections. Nitrofurazone has also been administered orally in the treatment of trypanosomiasis. [PubChem] The exact mechanism of action is unknown. Nitrofurazone inhibits several bacterial enzymes, especially those involved in the aerobic and anaerobic degradation of glucose and pyruvate. This activity is believed also to affect pyruvate dehydrogenase, citrate synthetase, malate dehydrogenase, glutathione reductase, and pyruvate decarboxylase.
Dược Động Học :
▧ Absorption :
Well absorbed.
▧ Metabolism :
Nitrofurans, including nitrofural, undergo metabolic reduction at the nitro group to generate reactive species which can covalently bind to cellular macromolecules (Polnaszek et al., 1984; Kutcher & McCalla, 1984; McCalla 1979; McCalla et al., 1975).
▧ Half Life :
5 hours
Độc Tính : Rat LD50 = 590 mg/kg; Allergic contact dermatitis is the most frequently reported adverse effect, occurring in approximately 1 % of patients treated.
Chỉ Định : For the treatement of bacterial skin infections including pyodermas, infected dermatoses and infections of cuts, wounds, burns and ulcers due to susceptible organisms.
Liều Lượng & Cách Dùng : Capsule - Oral
Dressing - Topical
Liquid - Intramuscular
Ointment - Topical
Powder - Oral
Powder - Topical
Powder, for solution - Oral
Solution - Intrauterine
Solution - Intravenous
Solution - Oral
Solution - Topical
Tablet - Oral
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Nitrofurazone powder
    Giá bán buôn : USD >0.63
    Đơn vị tính : g
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Furacin
  • Công ty :
    Sản phẩm biệt dược : Furaderm
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00336
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5447130
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506509
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C08042
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00862
ChemSpider
http://www.chemspider.com/Chemical-Structure.4566720.html
PharmGKB
http://www.pharmgkb.org/drug/PA164754877
Wikipedia
http://en.wikipedia.org/wiki/Nitrofurazone
Drugs.com
http://www.drugs.com/cons/nitrofurazone-topical.html
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