Tìm theo
Nitroarginine
Các tên gọi khác (12 ) :
  • L-NNA
  • N-nitro-l-arginine
  • N-omega-nitro-l-arginine
  • N(g)-nitro-l-arginine
  • N(g)-nitroarginine
  • N5-(Nitroamidino)-L-2,5-diaminopentanoic acid
  • NG-nitro-l-arginine
  • NG-NO2-L-Arg
  • Ngamma-nitro-l-arginine
  • Nitro-l-arginine
  • Nomega-nitro-l-arginine
  • NRG
enzyme inhibitors
Thuốc Gốc
Small Molecule
CAS: 2149-70-4
CTHH: C6H13N5O4
PTK: 219.1985
An inhibitor of nitric oxide synthetase which has been shown to prevent glutamate toxicity. Nitroarginine has been experimentally tested for its ability to prevent ammonia toxicity and ammonia-induced alterations in brain energy and ammonia metabolites. (Neurochem Res 1995:200(4):451-6)
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C6H13N5O4
Phân tử khối
219.1985
Monoisotopic mass
219.096753929
InChI
InChI=1S/C6H13N5O4/c7-4(5(12)13)2-1-3-9-6(8)10-11(14)15/h4H,1-3,7H2,(H,12,13)(H3,8,9,10)/t4-/m0/s1
InChI Key
InChIKey=MRAUNPAHJZDYCK-BYPYZUCNSA-N
IUPAC Name
(2S)-2-amino-5-(1-nitrocarbamimidamido)pentanoic acid
Traditional IUPAC Name
nitroarginine
SMILES
N[C@@H](CCCNC(=N)N[N+]([O-])=O)C(O)=O
Độ hòa tan
8.74e-01 g/l
logP
-3.4
logS
-2.4
pKa (strongest acidic)
1.83
pKa (Strongest Basic)
9.16
PSA
157.05 Å2
Refractivity
60.91 m3·mol-1
Polarizability
20.32 Å3
Rotatable Bond Count
6
H Bond Acceptor Count
8
H Bond Donor Count
5
Physiological Charge
0
Number of Rings
0
Bioavailability
1
Rule of Five
true
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB04223
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=440005
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508354
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C03417
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21958
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