Tìm theo
Nitric Oxide
Các tên gọi khác (20 ) :
  • (.)NO
  • (NO)(.)
  • [NO]
  • EDRF
  • endothelium-derived relaxing factor
  • Mononitrogen monoxide
  • Monoxido de nitrogeno
  • Monoxyde d'azote
  • Nitric oxide
  • nitrogen monooxide
  • Nitrogen monoxide
  • Nitrosyl
  • NO
  • NO(.)
  • Oxido de nitrogeno(ii)
  • Oxido nitrico
  • Oxyde azotique
  • Oxyde nitrique
  • Stickstoff(ii)-oxid
  • Stickstoffmonoxid
bronchodilator agents, endothelium dependent relaxing factors, free radical scavengers, neurotransmitte
Thuốc Gốc
Small Molecule
CAS: 10102-43-9
ATC: R07AX01
ĐG : Ino Therapeutics Inc. , http://inotherapeutics.com
CTHH: NO
PTK: 30.0061
Nitric oxide or Nitrogen monoxide is a chemical compound with chemical formula NO. This gas is an important signaling molecule in the body of mammals including humans and is an extremely important intermediate in the chemical industry. It is also a toxic air pollutant produced by automobile engines and power plants. Nitric oxide (NO) should not be confused with nitrous oxide (N2O), a general anaesthetic, or with nitrogen dioxide (NO2) which is another poisonous air pollutant. The nitric oxide molecule is a free radical, which is relevant to understanding its high reactivity. It reacts with the ozone in air to form nitrogen dioxide, signalled by the appearance of the reddish-brown color.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
NO
Phân tử khối
30.0061
Monoisotopic mass
29.997988627
InChI
InChI=1S/NO/c1-2
InChI Key
InChIKey=MWUXSHHQAYIFBG-UHFFFAOYSA-N
IUPAC Name
nitroso
Traditional IUPAC Name
nitric oxide
SMILES
[N]=O
Độ tan chảy
-163.6 °C
Độ sôi
-151.7 °C
Độ hòa tan
9.49E+004 mg/L
pKa (Strongest Basic)
-2.9
PSA
34.14 Å2
Refractivity
2.89 m3·mol-1
Polarizability
1.69 Å3
logP
0
Rotatable Bond Count
0
H Bond Acceptor Count
2
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
0
Bioavailability
1
Rule of Five
true
Dược Lực Học : Persistent pulmonary hypertension of the newborn (PPHN) occurs as a primary developmental defect or as a condition secondary to other diseases such as meconium aspiration syndrome (MAS), pneumonia, sepsis, hyaline membrane disease, congenital diaphragmatic hernia (CDH), and pulmonary hypoplasia. In these states, pulmonary vascular resistance (PVR) is high, which results in hypoxemia secondary to right-to-left shunting of blood through the patent ductus arteriosus and foramen ovale. In neonates with PPHN, Nitric oxide improves oxygenation (as indicated by significant increases in PaO2). Nitric oxide appears to increase the partial pressure of arterial oxygen (PaO2) by dilating pulmonary vessels in better entilated areas of the lung, redistributing pulmonary blood flow away from lung regions with low ventilation/perfusion (V/Q) ratios toward regions with normal ratios.
Cơ Chế Tác Dụng : Nitric oxide or Nitrogen monoxide is a chemical compound with chemical formula NO. This gas is an important signaling molecule in the body of mammals including humans and is an extremely important intermediate in the chemical industry. It is also a toxic air pollutant produced by automobile engines and power plants. Nitric oxide (NO) should not be confused with nitrous oxide (N2O), a general anaesthetic, or with nitrogen dioxide (NO2) which is another poisonous air pollutant. The nitric oxide molecule is a free radical, which is relevant to understanding its high reactivity. It reacts with the ozone in air to form nitrogen dioxide, signalled by the appearance of the reddish-brown color. Nitric oxide is a compound produced by many cells of the body. It relaxes vascular smooth muscle by binding to the heme moiety of cytosolic guanylate cyclase, activating guanylate cyclase and increasing intracellular levels of cyclic guanosine 3',5'-monophosphate, which then leads to vasodilation. When inhaled, nitric oxide produces pulmonary vasodilation.
Dược Động Học :
▧ Absorption :
Nitric oxide is absorbed systemically after inhalation.
▧ Metabolism :
via pulmonary capillary bed
▧ Route of Elimination :
Nitrate has been identified as the predominant nitric oxide metabolite excreted in the urine, accounting for >70% of the nitric oxide dose inhaled.
▧ Half Life :
2–6 seconds
Chỉ Định : For the treatment of term and near-term (>34 weeks) neonates with hypoxic respiratory failure
Liều Lượng & Cách Dùng : Gas - Respiratory (inhalation)
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : INOmax
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00435
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=145068
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506897
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C00533
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00074
ChemSpider
http://www.chemspider.com/Chemical-Structure.127983.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/64693-002-01
PharmGKB
http://www.pharmgkb.org/drug/PA450635
Wikipedia
http://en.wikipedia.org/wiki/Nitric_Oxide
RxList
http://www.rxlist.com/cgi/generic/inomax.htm
Drugs.com
http://www.drugs.com/mtm/nitric-oxide-inhalation-gas.html
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