Dược Động Học :
▧ Absorption :
The relative bioavailability of the suspension compared to the tablet was 70%. When administered with food the AUC and Cmax increased by two-fold and 50%, respectively, for the tablet and 45 to 50% and ≤ 10%, respectively, for the oral suspension.
▧ Protein binding :
Very High (greater than 99%), bound to proteins. Binding is not affected by degree of renal impairment.
▧ Metabolism :
Rapidly hydrolyzed to an active metabolite, tizoxanide (desacetyl-nitazoxanide), followed by conjugation, primarily by glucuronidation to tizoxanide glucuronide.
▧ Route of Elimination :
Tizoxanide is excreted in the urine, bile and feces, and tizoxanide glucuronide is excreted in urine and bile. Approximately two-thirds of the oral dose of nitazoxanide is excreted in the feces and one-third in the urine.
▧ Half Life :
3.5 hours in patients with normal renal function