Tìm theo
Nilvadipine
Các tên gọi khác (1) :
  • Nivadil
Thuốc Gốc
Small Molecule
CAS: 75530-68-6
ATC: C08CA10
CTHH: C19H19N3O6
PTK: 385.3707
Nilvadipine is a calcium channel blocker (CCB) for treatment of hypertension.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C19H19N3O6
Phân tử khối
385.3707
Monoisotopic mass
385.127385355
InChI
InChI=1S/C19H19N3O6/c1-10(2)28-19(24)15-11(3)21-14(9-20)17(18(23)27-4)16(15)12-6-5-7-13(8-12)22(25)26/h5-8,10,16,21H,1-4H3
InChI Key
InChIKey=FAIIFDPAEUKBEP-UHFFFAOYSA-N
IUPAC Name
3-methyl 5-propan-2-yl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Traditional IUPAC Name
3-isopropyl 5-methyl 6-cyano-2-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
SMILES
COC(=O)C1=C(NC(C)=C(C1C1=CC(=CC=C1)[N+]([O-])=O)C(=O)OC(C)C)C#N
Độ hòa tan
1.24e-02 g/l
logP
2.24
logS
-4.5
pKa (Strongest Basic)
-0.57
PSA
134.24 Å2
Refractivity
101.8 m3·mol-1
Polarizability
37.54 Å3
Rotatable Bond Count
7
H Bond Acceptor Count
6
H Bond Donor Count
1
Physiological Charge
0
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Nilvadipine is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nilvadipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Cơ Chế Tác Dụng : Nilvadipine is a calcium channel blocker (CCB) for treatment of hypertension. Nilvadipine inhibits the influx of extracellular calcium through myocardial and vascular membrane pores by physically plugging the channel. The decrease in intracellular calcium inhibits the contractile processes of smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.
Chỉ Định : For the management of vasospastic angina, chronic stable angina and hypertension.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Nivadil
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB06712
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=4494
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=99443264
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01908
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017328
PharmGKB
http://www.pharmgkb.org/drug/PA165958385
Wikipedia
http://en.wikipedia.org/wiki/Nilvadipine
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