Tìm theo
Niclosamide
Các tên gọi khác (1) :
  • Niclocide
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 50-65-7
ATC: P02DA01
CTHH: C13H8Cl2N2O4
PTK: 327.12
Niclosamide is used for the treatment of most tapeworm infections. Helminths (worms) are multicellular organisms that infect very large numbers of humans and cause a broad range of diseases. Over 1 billion people are infected with intestinal nematodes, and many millions are infected with filarial nematodes, flukes, and tapeworms. They are an even greater problem in domestic animals.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C13H8Cl2N2O4
Phân tử khối
327.12
Monoisotopic mass
325.986112168
InChI
InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
InChI Key
InChIKey=RJMUSRYZPJIFPJ-UHFFFAOYSA-N
IUPAC Name
5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
Traditional IUPAC Name
niclosamide
SMILES
OC1=C(C=C(Cl)C=C1)C(=O)NC1=C(Cl)C=C(C=C1)[N+]([O-])=O
Độ tan chảy
230 °C
Độ hòa tan
1.6 mg/L (at 20 °C)
logP
3.91
logS
-4.6
pKa (strongest acidic)
6.89
pKa (Strongest Basic)
-4.4
PSA
95.15 Å2
Refractivity
80.51 m3·mol-1
Polarizability
28.47 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
4
H Bond Donor Count
2
Physiological Charge
-1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Niclosamide is an antihelminth used against tapeworm infections. It may act by the uncoupling of the electron transport chain to ATP synthase. The disturbance of this crucial metabolic pathway prevents creation of adenosine tri-phosphate (ATP), an essential molecule that supplies energy for metabolism.
Cơ Chế Tác Dụng : Niclosamide is used for the treatment of most tapeworm infections. Helminths (worms) are multicellular organisms that infect very large numbers of humans and cause a broad range of diseases. Over 1 billion people are infected with intestinal nematodes, and many millions are infected with filarial nematodes, flukes, and tapeworms. They are an even greater problem in domestic animals. Niclosamide works by killing tapeworms on contact. Adult worms (but not ova) are rapidly killed, presumably due to uncoupling of oxidative phosphorylation or stimulation of ATPase activity. The killed worms are then passed in the stool or sometimes destroyed in the intestine. Niclosamide may work as a molluscicide by binding to and damaging DNA.
Dược Động Học :
▧ Absorption :
Niclosamide appears to be minimally absorbed from the gastrointestinal tract—neither the drug nor its metabolites have been recovered from the blood or urine.
Độc Tính : Infrequent, mild, and transitory adverse events include nausea, vomiting, diarrhea, and abdominal discomfort.
Chỉ Định : For the treatment of tapeworm and intestinal fluke infections: Taenia saginata (Beef Tapeworm), Taenia solium (Pork Tapeworm), Diphyllobothrium latum (Fish Tapeworm), Fasciolopsis buski (large intestinal fluke). Niclosamide is also used as a molluscicide in the control of schistosomiasis.
Liều Lượng & Cách Dùng : Tablet, chewable - Oral
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Niclocide
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB06803
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=4477
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=99443295
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00436
ChemSpider
http://www.chemspider.com/Chemical-Structure.4322.html
PharmGKB
http://www.pharmgkb.org/drug/PA165958408
Wikipedia
http://en.wikipedia.org/wiki/Niclosamide
Drugs.com
http://www.drugs.com/cons/niclosamide.html
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