Tìm theo
Nicergoline
Các tên gọi khác (5 ) :
  • Nicergolin
  • Nicergolina
  • Nicergoline
  • Nicergolinum
  • Sermion
Thuốc điều trị về tâm thần
Thuốc Gốc
Small Molecule
CAS: 27848-84-6
ATC: C04AE02
CTHH: C24H26BrN3O3
PTK: 484.386
An ergot derivative that has been used as a cerebral vasodilator and in peripheral vascular disease. It has been suggested to ameliorate cognitive deficits in cerebrovascular disease. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C24H26BrN3O3
Phân tử khối
484.386
Monoisotopic mass
483.11575436
InChI
InChI=1S/C24H26BrN3O3/c1-27-13-17-8-21-24(30-3,19-5-4-6-20(27)22(17)19)9-15(12-28(21)2)14-31-23(29)16-7-18(25)11-26-10-16/h4-7,10-11,13,15,21H,8-9,12,14H2,1-3H3/t15-,21-,24+/m1/s1
InChI Key
InChIKey=YSEXMKHXIOCEJA-FVFQAYNVSA-N
IUPAC Name
[(2S,4R,7R)-2-methoxy-6,11-dimethyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),9,12,14-tetraen-4-yl]methyl 5-bromopyridine-3-carboxylate
Traditional IUPAC Name
nicergoline
SMILES
[H][C@@]12CC3=CN(C)C4=CC=CC(=C34)[C@]1(C[C@@H](COC(=O)C1=CC(Br)=CN=C1)CN2C)OC
Độ hòa tan
1.27e-02 g/l
logP
3.3
logS
-4.6
pKa (Strongest Basic)
8.14
PSA
56.59 Å2
Refractivity
123.3 m3·mol-1
Polarizability
48.08 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
4
H Bond Donor Count
0
Physiological Charge
1
Number of Rings
5
Bioavailability
1
Rule of Five
true
Dược Lực Học : Nicergoline is a potent vasodilator (improves brain blood flow). On the cerebral level it prompts a lowering of vascular resistance, an increase in arterial flow and stimulates the use of oxygen and glucose. Nicergoline also improves blood circulation in the lungs and limbs and has been shown to inhibit blood platelet aggregation.
Cơ Chế Tác Dụng : An ergot derivative that has been used as a cerebral vasodilator and in peripheral vascular disease. It has been suggested to ameliorate cognitive deficits in cerebrovascular disease. [PubChem] Nicergoline acts by inhibiting the postsynaptic alpha(1)-adrenoceptors on vascular smooth muscle. This inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation. Therefore the mechanism of Nicergoline is to increase vascular circulation in the brain, thereby enhancing the transmission of nerve signals across the nerve fibres, which secrete acetylcholine as a neural transmitter.
Chỉ Định : For the treatment of senile dementia, migraines of vascular origin, transient ischemia, platelet hyper-aggregability, and macular degeneration.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Sermion
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00699
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=34040
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508741
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01290
ChemSpider
http://www.chemspider.com/Chemical-Structure.31373.html
PharmGKB
http://www.pharmgkb.org/drug/PA164743014
Wikipedia
http://en.wikipedia.org/wiki/Nicergoline
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