Tìm theo
NGX-4010
sensory system agents
Thuốc Gốc
Small Molecule
CTHH: C18H27NO3
PTK: 305.4119
NGX-4010 is a NeurogesX's novel high-concentration trans-capsaicin dermal patch.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C18H27NO3
Phân tử khối
305.4119
Monoisotopic mass
305.199093735
InChI
InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+
InChI Key
InChIKey=YKPUWZUDDOIDPM-SOFGYWHQSA-N
IUPAC Name
(6E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide
Traditional IUPAC Name
capsaicin
SMILES
COC1=C(O)C=CC(CNC(=O)CCCC\C=C\C(C)C)=C1
Độ hòa tan
8.41e-03 g/l
logP
3.75
logS
-4.6
pKa (strongest acidic)
9.93
pKa (Strongest Basic)
-0.52
PSA
58.56 Å2
Refractivity
90.32 m3·mol-1
Polarizability
36.32 Å3
Rotatable Bond Count
9
H Bond Acceptor Count
3
H Bond Donor Count
2
Physiological Charge
0
Number of Rings
1
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Cơ Chế Tác Dụng : NGX-4010 is a NeurogesX's novel high-concentration trans-capsaicin dermal patch. NGX-4010 is a topical, physician administered patch containing a high concentration of trans-capsaicin, a synthetic form of the naturally occurring capsaicin and the ingredient that makes chili peppers hot. The patch is designed to act peripherally, or in the skin, where the pain frequently originates, unlike current treatment approaches for neuropathic pain that include opioids and other agents acting on the central nervous system that can cause drowsiness or other systemic side effects. Due to the novel patch delivery system and dermal site of action of NGX-4010, the potential for safety issues or side effects that negatively impact quality of life is expected to be low.
Chỉ Định : Investigated for use/treatment in neurologic disorders, pain (acute or chronic), and post herpetic neuralgia.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Transacin
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05318
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=1548943
ChemSpider
http://www.chemspider.com/Chemical-Structure.1265957.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=20461
Wikipedia
http://en.wikipedia.org/wiki/Capsaicin
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