Tìm theo
Neramexane
Thuốc Gốc
Small Molecule
CAS: 219810-59-0
CTHH: C11H23N
PTK: 169.307
Neramexane is a low-to-moderate affinity uncompetitive NMDA receptor antagonist.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C11H23N
Phân tử khối
169.307
Monoisotopic mass
169.183049741
InChI
InChI=1S/C11H23N/c1-9(2)6-10(3,4)8-11(5,12)7-9/h6-8,12H2,1-5H3
InChI Key
InChIKey=OGZQTTHDGQBLBT-UHFFFAOYSA-N
IUPAC Name
1,3,3,5,5-pentamethylcyclohexan-1-amine
Traditional IUPAC Name
neramexane
SMILES
CC1(C)CC(C)(C)CC(C)(N)C1
Độ hòa tan
6.29e-02 g/l
logP
2.63
logS
-3.4
pKa (Strongest Basic)
10.66
PSA
26.02 Å2
Refractivity
53.62 m3·mol-1
Polarizability
21.66 Å3
Rotatable Bond Count
0
H Bond Acceptor Count
1
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
1
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Neramexane is similar to memantine and acetylcholinesterase inhibitors in that neramexane targets the cognitive decline in Alzheimer’s Disease by altering neurotransmitter signaling, but not the underlying pathological mechanisms that cause the disease (amyloid production or neurofibrillary tangle accumulation).
Cơ Chế Tác Dụng : Neramexane is a low-to-moderate affinity uncompetitive NMDA receptor antagonist. Neramexane is an uncompetitive NMDA receptor channel blocker.
Chỉ Định : Investigated for use/treatment in alzheimer's disease, hearing loss, and pain (acute or chronic).
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Xaprila
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB04926
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=6433106
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=10549697
ChemSpider
http://www.chemspider.com/Chemical-Structure.4938294.html
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