Tìm theo
NCX 4016
Thuốc Gốc
Small Molecule
NCX 4016 is studied in the prevention of colorectal cancer. It is a form of aspirin that gives off nitric oxide gas and is less irritating to the lining of the stomach than plain aspirin. It is a type of nonsteroidal anti-inflammatory drug (NSAID) and also called as nitric oxide-releasing acetylsalicylic acid derivative.
Cơ Chế Tác Dụng : NCX 4016 is studied in the prevention of colorectal cancer. It is a form of aspirin that gives off nitric oxide gas and is less irritating to the lining of the stomach than plain aspirin. It is a type of nonsteroidal anti-inflammatory drug (NSAID) and also called as nitric oxide-releasing acetylsalicylic acid derivative. NCX-4016 is new chemical entities obtained by adding a nitric oxide-releasing moiety to aspirin. NCX-4016 consists of the parent molecule (aspirin) linked to a 'spacer' via an ester linkage, which is in turn connected to a nitric oxide-releasing moiety. Both aspirin and NCX-4016 contribute to its effectiveness, the latter occurring via both cyclic guanosyl monophosphate-dependent and -independent mechanisms.
Chỉ Định : Investigated for use/treatment in cardiovascular disorders, colorectal cancer, diabetes mellitus type 2, peripheral vascular disease, and thrombosis.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05822
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