Tìm theo
NB-002
Thuốc Gốc
Small Molecule
NB-002 is a drug candidate for the topical treatment of onychomycosis, a fungal infection of the fingernail and toenail. It is a topical oil-in-water nanoemulsion combined with an antimicrobial agent commonly used in oral products to treat gingivitis and other conditions of the mouth and throat. The nanoemulsion undergoes a high-energy process to shrink or “nano-size” the particles so they are small enough to enter the skin through pores and hair follicles but too large to penetrate the tight junctions of the epithelium.
Cơ Chế Tác Dụng : NB-002 is a drug candidate for the topical treatment of onychomycosis, a fungal infection of the fingernail and toenail. It is a topical oil-in-water nanoemulsion combined with an antimicrobial agent commonly used in oral products to treat gingivitis and other conditions of the mouth and throat. The nanoemulsion undergoes a high-energy process to shrink or “nano-size” the particles so they are small enough to enter the skin through pores and hair follicles but too large to penetrate the tight junctions of the epithelium. NB-002 is a unique topical oil-in-water emulsion composed of high-energy, positively charged, nanometer-sized antifungal particles. The nanoparticles traverse the pores and hair follicles without irritating the epithelium or being absorbed systemically. They bind to the lipids in the fungal cell membrane, disrupting the membrane and lysing the cell. This physical process has a lower risk for the development of drug resistance than a biochemical approach. Unlike current antifungals, NB-002 also kills the resting (spore) form of the fungi by inducing germination, limiting the potential for disease recurrence.
Chỉ Định : Investigated for use/treatment in onychomycosis.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05748
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