Tìm theo
Natamycin
Các tên gọi khác (7 ) :
  • Natacyn
  • Natamicina
  • Natamycin
  • Natamycine
  • Natamycinum
  • Pimaricin
  • PMR
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 7681-93-8
ATC: A01AB10, A07AA03, D01AA02, G01AA02, S01AA10
ĐG : Alcon Laboratories , http://www.alcon.com
CTHH: C33H47NO13
PTK: 665.7252
Amphoteric macrolide antifungal antibiotic from Streptomyces natalensis or S. chattanoogensis. It is used for a variety of fungal infections, mainly topically. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C33H47NO13
Phân tử khối
665.7252
Monoisotopic mass
665.304740595
InChI
InChI=1S/C33H47NO13/c1-18-10-8-6-4-3-5-7-9-11-21(45-32-30(39)28(34)29(38)19(2)44-32)15-25-27(31(40)41)22(36)17-33(42,47-25)16-20(35)14-24-23(46-24)12-13-26(37)43-18/h3-9,11-13,18-25,27-30,32,35-36,38-39,42H,10,14-17,34H2,1-2H3,(H,40,41)/b4-3+,7-5+,8-6+,11-9+,13-12+/t18-,19-,20+,21+,22+,23-,24-,25+,27-,28+,29-,30+,32?,33-/m1/s1
InChI Key
InChIKey=NCXMLFZGDNKEPB-BQGNJOPGSA-N
IUPAC Name
(1R,3S,5R,7R,12R,22R,24S,25R,26S)-22-{[(3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.0^{5,7}]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid
Traditional IUPAC Name
(1R,3S,5R,7R,12R,22R,24S,25R,26S)-22-{[(3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.0^{5,7}]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid
SMILES
C[C@H]1OC(O[C@@H]2C[C@@H]3O[C@@](O)(C[C@H](O)[C@H]3C(O)=O)C[C@@H](O)C[C@H]3O[C@@H]3\C=C\C(=O)O[C@H](C)C\C=C\C=C\C=C\C=C\2)[C@@H](O)[C@@H](N)[C@@H]1O
Độ tan chảy
290 dec °C
Độ hòa tan
4100 mg/L (at 21 °C)
logP
1.1
logS
-3.21
pKa (strongest acidic)
3.58
pKa (Strongest Basic)
9.11
PSA
230.99 Å2
Refractivity
169.88 m3·mol-1
Polarizability
68.19 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
13
H Bond Donor Count
7
Physiological Charge
0
Number of Rings
4
Bioavailability
0
Dược Lực Học : Natamycin is an antifungal drug for topical ophthalmic administration. It is a tetraene polyene antibiotic derived from Streptomyces natalensis. It possesses in vitro activity against a variety of yeast and filamentous fungi, including Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium. Although the activity against fungi is dose-related, natamycin is predominantly fungicidal. Natamycin is not effective in vitro against gram-positive or gram-negative bacteria. Topical administration appears to produce effective concentrations of natamycin within the corneal stroma but not in intraocular fluid.
Cơ Chế Tác Dụng : Amphoteric macrolide antifungal antibiotic from Streptomyces natalensis or S. chattanoogensis. It is used for a variety of fungal infections, mainly topically. [PubChem] LIke other polyene antibiotics, Natamycin inhibits fungal growth by binding to sterols. Specifically, Natamycin binds to ergosterol in the plasma membrane, preventing ergosterol-dependent fusion of vacuoles, as well as membrane fusion and fission. This differs from the mechanism of most other polyene antibiotics, which tend to work by altering fungal membrane permeability instead.
Dược Động Học :
▧ Absorption :
Systemic absorption should not be expected following topical administration, and as with other polyene antibiotics, absorption from the gastrointestinal tract is very poor.
Chỉ Định : For the treatment of fungal blepharitis, conjunctivitis, and keratitis caused by susceptible organisms including Fusarium solani keratitis.
Liều Lượng & Cách Dùng : Suspension / drops - Ophthalmic
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Natacyn eye drops
    Giá bán buôn : USD >14.16
    Đơn vị tính : ml
Nhà Sản Xuất
  • Công ty : Sanbe
    Sản phẩm biệt dược : Fukricin
  • Công ty : Infectopharm
    Sản phẩm biệt dược : InfectoMyk
  • Công ty : Aristopharma
    Sản phẩm biệt dược : N-Mycin
  • Công ty : Alcon
    Sản phẩm biệt dược : Natacyn
  • Công ty : Cipla
    Sản phẩm biệt dược : Natadrops
  • Công ty : Sun
    Sản phẩm biệt dược : Natamet
  • Công ty : Unia
    Sản phẩm biệt dược : Natamycyna
  • Công ty : Alcon
    Sản phẩm biệt dược : Natezhen
  • Công ty : Ibn Sina
    Sản phẩm biệt dược : Natoph
  • Công ty : FDC
    Sản phẩm biệt dược : Natoptic
  • Công ty : Jayson
    Sản phẩm biệt dược : Optinat
  • Công ty : Astellas
    Sản phẩm biệt dược : Pimafucin
  • Công ty : Elder
    Sản phẩm biệt dược : Pimafusin
  • Công ty : Senju Seiyaku
    Sản phẩm biệt dược : Pimaricin
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00826
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5281099
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46509171
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C08073
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00884
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0065-0645-15
PharmGKB
http://www.pharmgkb.org/drug/PA164744325
Wikipedia
http://en.wikipedia.org/wiki/Natamycin
RxList
http://www.rxlist.com/cgi/generic2/natamycin.htm
Drugs.com
http://www.drugs.com/cdi/natamycin.html
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