Tìm theo
Naphazoline
Các tên gọi khác (1) :
  • Nafazolin
Thuốc dùng điều trị mắt, tai mũi họng
Thuốc Gốc
Small Molecule
CAS: 835-31-4
ATC: R01AA08, S01GA01, R01AB02
CTHH: C14H14N2
PTK: 210.2744
Naphazoline is a rapid acting sympathomimetic vasoconstrictor of occular artierioles. It acts to decrease congestion of the conjunctiva and is found in many over-the-counter eye drops.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C14H14N2
Phân tử khối
210.2744
Monoisotopic mass
210.115698458
InChI
InChI=1S/C14H14N2/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14/h1-7H,8-10H2,(H,15,16)
InChI Key
InChIKey=CNIIGCLFLJGOGP-UHFFFAOYSA-N
IUPAC Name
2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole
Traditional IUPAC Name
naphazoline
SMILES
C(C1=NCCN1)C1=CC=CC2=CC=CC=C12
Độ hòa tan
3.81e-02 g/l
logP
2.19
logS
-3.7
pKa (Strongest Basic)
10.19
PSA
24.39 Å2
Refractivity
65.52 m3·mol-1
Polarizability
23.77 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
2
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Naphazoline is a direct acting sympathomimetic adrenergic alpha-agonist used to induce systemic vasoconstriction, thereby decreasing nasal congestion and inducing constriction around the conjunctiva. The sympathomimetic action of Naphazoline constricts the smaller arterioles of the nasal passages, producing a decongesting effect. Naphazoline ophthalmic causes constriction of blood vessels in the eyes. It also decreases itching and irritation of the eyes. aphazoline constricts the vascular system of the conjunctiva. It is presumed that this effect is due to direct stimulation action of the drug upon the alpha adrenergic receptors in the arterioles of the conjunctiva resulting in decreased conjunctival congestion. Naphazoline belongs to the imidazoline class of sympathomimetics.
Cơ Chế Tác Dụng : Naphazoline is a rapid acting sympathomimetic vasoconstrictor of occular artierioles. It acts to decrease congestion of the conjunctiva and is found in many over-the-counter eye drops. Naphazoline is a direct acting sympathomimetic drug, which acts on alpha-adrenergic receptors in the arterioles of the nasal mucosa. This activates the adrenal system to yield systemic vasoconstrction. In producing vasoconstriction, the result is a decrease in blood flow in the nasal passages and consequently decreased nasal congestion. The vasoconstriction means that there is less pressure in the capillaries and less water can filter out, thus less discharge is made.
Độc Tính : Extended usage of Naphazoline can result in decreased effectiveness or a build up of tolerance against the drug. The number of receptors decreases, and when the administration of the drug is ceased, chronic congestion can occur; this is called rhinitis medicamentosa, commonly referred to as rebound congestion. Moreover long-term overdosing can cause degenerative changes in nasal mucous membranes that pose another health problem.
Chỉ Định : Naphazoline is primarily indicated in conditions like Corneal vascularity, Hyperaemia, Itching, Nasal congestion, and can also be given in adjunctive therapy as an alternative drug of choice in Sinusitis
Liều Lượng & Cách Dùng : Solution / drops - Ophthalmic - 0.1%
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : AK-Con
  • Công ty :
    Sản phẩm biệt dược : Albalon
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB06711
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=4436
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=99443263
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D08253
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50027061
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/21695-915
PharmGKB
http://www.pharmgkb.org/drug/PA165958384
Wikipedia
http://en.wikipedia.org/wiki/Naphazoline
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