Tìm theo
naltrexone depot
Thuốc Gốc
Small Molecule
CTHH: C20H24ClNO4
PTK: 377.862
Naltrexone depot produced statistically significant blockade of opiate effects for six weeks as measured by subjective rating scales and measurement of pupil size.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C20H24ClNO4
Phân tử khối
377.862
Monoisotopic mass
377.139385968
InChI
InChI=1S/C20H23NO4.ClH/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11;/h3-4,11,15,18,22,24H,1-2,5-10H2;1H/t15-,18+,19+,20-;/m1./s1
InChI Key
InChIKey=RHBRMCOKKKZVRY-ITLPAZOVSA-N
IUPAC Name
(1S,5R,13R,17S)-4-(cyclopropylmethyl)-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10-trien-14-one hydrochloride
Traditional IUPAC Name
naltrexone hydrochloride
SMILES
Cl.[H][C@@]12OC3=C(O)C=CC4=C3[C@@]11CCN(CC3CC3)[C@]([H])(C4)[C@]1(O)CCC2=O
logP
1.36
pKa (strongest acidic)
7.39
pKa (Strongest Basic)
11.54
PSA
70 Å2
Refractivity
91.5 m3·mol-1
Polarizability
35.97 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
5
H Bond Donor Count
2
Physiological Charge
1
Number of Rings
6
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Cơ Chế Tác Dụng : Naltrexone depot produced statistically significant blockade of opiate effects for six weeks as measured by subjective rating scales and measurement of pupil size. Naltrexone depot blocks the effects of hydromorphone, an opiate similar in effects to heroin.
Chỉ Định : Investigated for use/treatment in alcohol dependence.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Naltrel
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05302
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5485201
ChemSpider
http://www.chemspider.com/Chemical-Structure.4588651.html
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