Tìm theo
Naftifine
Các tên gọi khác (5 ) :
  • Naftifin
  • Naftifina
  • Naftifine
  • Naftifinum
  • Naftin
Thuốc Gốc
Small Molecule
CAS: 65472-88-0
ATC: D01AE22
ĐG : DPT Laboratories Ltd. , http://www.dptlabs.com
CTHH: C21H21N
PTK: 287.3981
Naftifine is a synthetic, broad spectrum, antifungal agent and allylamine derivative for the topical treatment of tinea pedis, tinea cruris, and tinea corporis caused by the organisms Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans and Epidermophyton floccosum.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C21H21N
Phân tử khối
287.3981
Monoisotopic mass
287.167399677
InChI
InChI=1S/C21H21N/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20/h2-15H,16-17H2,1H3/b11-8+
InChI Key
InChIKey=OZGNYLLQHRPOBR-DHZHZOJOSA-N
IUPAC Name
methyl(naphthalen-1-ylmethyl)(3-phenylprop-2-en-1-yl)amine
Traditional IUPAC Name
methyl(naphthalen-1-ylmethyl)(3-phenylprop-2-en-1-yl)amine
SMILES
CN(CC=CC1=CC=CC=C1)CC1=CC=CC2=CC=CC=C12
Độ hòa tan
2.29e-04 g/l
logP
5.4
logS
-6.1
pKa (Strongest Basic)
9.08
PSA
3.24 Å2
Refractivity
95.98 m3·mol-1
Polarizability
34.05 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
1
H Bond Donor Count
0
Physiological Charge
1
Number of Rings
3
Bioavailability
1
Ghose Filter
true
Dược Lực Học : Naftifine is a synthetic, broad spectrum, antifungal agent and allylamine derivative. The following in vitro data are available, but their clinical significance is unknown. Naftifine has been shown to exhibit fungicidal activity in vitro against a broad spectrum of organisms including Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Epidermophyton floccosum, and Microsporum canis, Microsporum audouini, and Microsporum gypseum; and fungistatic activity against Candida species including Candida albicans. However it is only used to treat the organisms listed in the indications.
Cơ Chế Tác Dụng : Naftifine is a synthetic, broad spectrum, antifungal agent and allylamine derivative for the topical treatment of tinea pedis, tinea cruris, and tinea corporis caused by the organisms Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans and Epidermophyton floccosum. Although the exact mechanism of action against fungi is not known, naftifine appears to interfere with sterol biosynthesis by inhibiting the enzyme squalene 2,3-epoxidase. This inhibition of enzyme activity results in decreased amounts of sterols, especially ergosterol, and a corresponding accumulation of squalene in the cells.
Dược Động Học :
▧ Absorption :
Following single topical applications of 3H-labeled naftifine gel 1% to the skin of healthy subjects, up to 4.2% of the applied dose was absorbed.
▧ Route of Elimination :
Naftifine and/or its metabolites are excreted via the urine and feces with a half-life of approximately two to three days.
▧ Half Life :
Approximately 2 to 3 days following topical administration.
Chỉ Định : For the topical treatment of tinea pedis, tinea cruris, and tinea corporis caused by the organisms Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans and Epidermophyton floccosum.
Liều Lượng & Cách Dùng : Cream - Topical
Gel - Topical
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Shou Chan
    Sản phẩm biệt dược : A Mei
  • Công ty : Yuan Chou
    Sản phẩm biệt dược : Ancent
  • Công ty : Sandoz
    Sản phẩm biệt dược : Exoderil
  • Công ty : Bayer
    Sản phẩm biệt dược : Micosona
  • Công ty : Antibiotice
    Sản phẩm biệt dược : Naftifina
  • Sản phẩm biệt dược : Naftin
  • Công ty : Sandoz
    Sản phẩm biệt dược : Suadian
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00735
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=47641
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504777
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C08071
ChemSpider
http://www.chemspider.com/Chemical-Structure.66071.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0259-4770-40
PharmGKB
http://www.pharmgkb.org/drug/PA164748617
Wikipedia
http://en.wikipedia.org/wiki/Naftifine
RxList
http://www.rxlist.com/cgi/generic2/naft.htm
Drugs.com
http://www.drugs.com/cdi/naftifine-cream.html
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