Tìm theo
Muromonab
Các tên gọi khác (2) :
  • Anti-CD3
  • Muromonab-CD3
immunologic factors, immunosuppressive agents
Thuốc Gốc
Biotech
CAS: 140608-64-6
ATC: L04AA02
ĐG : Centocor Ortho Biotech Inc. , http://www.centocororthobiotech.com
CTHH: C6460H9946N1720O2043S56
PTK: 146189.7000
Murine monoclonal antibody specific to CD3 T-cell lymphocyte antigens. More specifically it is a purified murine (mouse) monoclonal antibody, directed against the CD3 (T3) receptor on the surface of human T-cells (T-lymphocytes) cultured using the murine ascites method. Muromonab is 93% monomeric immune globulin G type 2a (IgG2a).
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C6460H9946N1720O2043S56
Phân tử khối
146189.7000
Độ tan chảy
61 °C (FAB fragment), 71 °C (whole mAb)
Độ kỵ nước
-0.513
Điểm đẳng điện tích
8.31
Dược Lực Học : Used in organ transplant prophylaxis, Muromonab or OKT-3 binds specifically to the CD-3 complex, which is involved in antigen recognition and cell stimulation, on the surface of T lymphocytes. Immediately after administration CD-3-positive T lymphocytes are abruptly removed from circulation. It has been effective in reversing corticosteroid-resistant acute rejection in renal, liver, and cardiac transplant recipients.
Cơ Chế Tác Dụng : Murine monoclonal antibody specific to CD3 T-cell lymphocyte antigens. More specifically it is a purified murine (mouse) monoclonal antibody, directed against the CD3 (T3) receptor on the surface of human T-cells (T-lymphocytes) cultured using the murine ascites method. Muromonab is 93% monomeric immune globulin G type 2a (IgG2a). Muromonab binds to the T-cell surface glycoprotein CD3 epsilon chain. It appears to kill CD-3 positive cells by inducing Fc mediated apoptosis, antibody mediated cytotoxicity and complement-dependent cytotoxicity.
Dược Động Học :

▧ Metabolism :
Most likely removed by opsonization via the reticuloendothelial system when bound to T lymphocytes, or by human antimurine antibody production
▧ Half Life :
0.8 hours (mammalian reticulocytes, in vitro)
Chỉ Định : For treatment of organ transplant recipients, prevention of organ rejection
Tương Tác Thuốc :
  • Cyclosporine Muromonab increases the levels of cyclosporine
  • Rilonacept results in increased immunosuppressive effects; increases the risk of infection.
  • Trastuzumab Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Liều Lượng & Cách Dùng : Solution - Intravenous
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Janssen-Cilag
    Sản phẩm biệt dược : Orthoclone OKT3
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00075
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D05092
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/59676-101-01
PharmGKB
http://www.pharmgkb.org/drug/PA164743097
Wikipedia
http://en.wikipedia.org/wiki/Muromonab
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