Tìm theo
MPC-7869
Thuốc Gốc
Small Molecule
CTHH: C15H13FO2
PTK: 244.2609
FLURIZAN tarenflurbil is an investigational drug being studied in patients with mild Alzheimer's disease. It is a selective amyloid lowering agent (SALA) that reduces levels of the toxic peptide amyloid beta 42 (Aβ42) in cultured human cells and in animal models. Aβ42 is the primary initiator of neurotoxicity and amyloid plaque development in the brains of Alzheimer's disease patients.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C15H13FO2
Phân tử khối
244.2609
Monoisotopic mass
244.089957865
InChI
InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)/t10-/m1/s1
InChI Key
InChIKey=SYTBZMRGLBWNTM-SNVBAGLBSA-N
IUPAC Name
(2R)-2-(3-fluoro-4-phenylphenyl)propanoic acid
Traditional IUPAC Name
flurbiprofen
SMILES
C[C@@H](C(O)=O)C1=CC(F)=C(C=C1)C1=CC=CC=C1
Độ hòa tan
2.49e-02 g/l
logP
3.94
logS
-4
pKa (strongest acidic)
4.42
PSA
37.3 Å2
Refractivity
67.29 m3·mol-1
Polarizability
25.31 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
2
H Bond Donor Count
1
Physiological Charge
-1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Cơ Chế Tác Dụng : FLURIZAN tarenflurbil is an investigational drug being studied in patients with mild Alzheimer's disease. It is a selective amyloid lowering agent (SALA) that reduces levels of the toxic peptide amyloid beta 42 (Aβ42) in cultured human cells and in animal models. Aβ42 is the primary initiator of neurotoxicity and amyloid plaque development in the brains of Alzheimer's disease patients. MPC-7869 is not an inhibitor of cyclooxygenase enzymes (COX-1 and COX-2). The compound modulates the signal transduction and transcription activation pathways associated with nuclear factor kappaB (NFkappaB), a principle transcription factor in the expression of many molecules involved in cell growth, cell death and inflammation. In addition, MPC-7869 has recently been shown to modulate gamma-secretase and selectively lower levels of Abeta42 peptide in vitro and in vivo, and to reduce amyloid pathology in the brain. MPC-7869 has an excellent safety profile and is very potent in animal models of cancer and Alzheimer's disease. In transgenic mouse studies, MPC-7869 reduced brain amyloid levels and prevented memory loss.
Chỉ Định : Investigated for use/treatment in alzheimer's disease and prostate cancer.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Flurizan
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05289
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=92337
ChemSpider
http://www.chemspider.com/Chemical-Structure.83361.html
Wikipedia
http://en.wikipedia.org/wiki/Flurizan
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