Tìm theo
Monobenzone
Các tên gọi khác (16 ) :
  • 4-(Benzyloxy)phenol
  • 4-(Benzyloxyl)phenol
  • 4-(Phenylmethoxy)phenol
  • 4-Benzyloxy-phenol
  • 4-Benzyloxyphenol
  • Benzyl p-hydroxyphenyl ether
  • Hydrochinon monobenzylether
  • Hydroquinone benzyl ether
  • Hydroquinone monobenzyl ether
  • Monobenzona
  • Monobenzone
  • Monobenzonum
  • MONOBENZYL ether OF hydroquinone
  • Monobenzyl hydroquinone
  • p-(Benzyloxy)phenol
  • p-Hydroxyphenyl benzyl ether
dermatologic agents
Thuốc Gốc
Small Molecule
CAS: 103-16-2
ATC: D11AX13
ĐG : Legacy Pharmaceuticals Packaging LLC , http://www.legacypackaging.com
CTHH: C13H12O2
PTK: 200.2332
Monobenzone is the monobenzyl ether of hydroquinone used medically for depigmentation. Monobenzone occurs as a white, almost tasteless crystalline powder, soluble in alcohol and practically insoluble in water. The topical application of monobenzone in animals increases the excretion of melanin from the melanocytes. The same action is thought to be responsible for the depigmenting effect of the drug in humans. Monobenzone may cause destruction of melanocytes and permanent depigmentation.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C13H12O2
Phân tử khối
200.2332
Monoisotopic mass
200.083729628
InChI
InChI=1S/C13H12O2/c14-12-6-8-13(9-7-12)15-10-11-4-2-1-3-5-11/h1-9,14H,10H2
InChI Key
InChIKey=VYQNWZOUAUKGHI-UHFFFAOYSA-N
IUPAC Name
4-(benzyloxy)phenol
Traditional IUPAC Name
monobenzone
SMILES
OC1=CC=C(OCC2=CC=CC=C2)C=C1
Độ tan chảy
122 °C
Độ hòa tan
251 mg/L
logP
3.2
logS
-3.7
pKa (strongest acidic)
9.91
pKa (Strongest Basic)
-4.8
PSA
29.46 Å2
Refractivity
59.11 m3·mol-1
Polarizability
21.91 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
2
H Bond Donor Count
1
Physiological Charge
0
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Monobenzone is the monobenzyl ether of hydroquinone. Monobenzone, applied topically to the skin, is used as a depigmenting agent inhibitting melanin produced by polymerization of oxidation products of tyrosine and dihydroxyphenyl compounds. Monobenzone works by permanently removing color from normal skin located around skin with vitiligo.
Cơ Chế Tác Dụng : Monobenzone is the monobenzyl ether of hydroquinone used medically for depigmentation. Monobenzone occurs as a white, almost tasteless crystalline powder, soluble in alcohol and practically insoluble in water. The topical application of monobenzone in animals increases the excretion of melanin from the melanocytes. The same action is thought to be responsible for the depigmenting effect of the drug in humans. Monobenzone may cause destruction of melanocytes and permanent depigmentation. Monobenzone is a depigmenting agent whose mechanism of action is not fully understood. The topical application of monobenzone in animals, increases the excretion of melanin from the melanocytes. The same action is thought to be responsible for the depigmenting effect of the drug in humans. Monobenzone may cause destruction of melanocytes and permanent depigmentation. This effect is erratic and may take one to four months to occur while existing melanin is lost with normal sloughing of the stratum corneum. Hyperpigmented skin appears to fade more rapidly than does normal skin, and exposure to sunlight reduces the depigmenting effect of the drug. The histology of the skin after depigmentation with topical monobenzone is the same as that seen in vitiligo; the epidermis is normal except for the absence of identifiable melanocytes.
Chỉ Định : Used topically to treat the loss of skin color (vitiligo).
Liều Lượng & Cách Dùng : Cream - Topical
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Benoquin
  • Công ty : Vis
    Sản phẩm biệt dược : Monobenzone
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00600
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=7638
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507466
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C14244
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D05072
ChemSpider
http://www.chemspider.com/Chemical-Structure.7356.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0187-0380-34
PharmGKB
http://www.pharmgkb.org/drug/PA164764582
Wikipedia
http://en.wikipedia.org/wiki/Monobenzone
Drugs.com
http://www.drugs.com/mtm/monobenzone-topical.html
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