Tìm theo
MLN-1202
Thuốc Gốc
Small Molecule
MLN1202, a novel humanized monoclonal antibody, specifically targets CCR2 chemokine receptors found on the surface of certain white blood cells including macrophages and monocytes. Preclinical studies suggest that CCR2 plays an important role in the trafficking of monocytes and macrophages to sites of inflammation. The recruitment of macrophages to the arterial wall is believed to be a critical step in the development of atherosclerosis. MLN1202 fully met the primary endpoint in Phase II clinical study of patients at high risk for atherosclerosis
Dược Lực Học : MLN1202, a novel humanized monoclonal antibody, specifically targets CCR2 chemokine receptors found on the surface of certain white blood cells including macrophages and monocytes. MLN1202 is indicated for the treatment of patients at high risk for atherosclerosis
Cơ Chế Tác Dụng : MLN1202, a novel humanized monoclonal antibody, specifically targets CCR2 chemokine receptors found on the surface of certain white blood cells including macrophages and monocytes. Preclinical studies suggest that CCR2 plays an important role in the trafficking of monocytes and macrophages to sites of inflammation. The recruitment of macrophages to the arterial wall is believed to be a critical step in the development of atherosclerosis. MLN1202 fully met the primary endpoint in Phase II clinical study of patients at high risk for atherosclerosis Preclinical studies suggest that CCR2 plays an important role in the trafficking of monocytes and macrophages to sites of inflammation. The recruitment of macrophages to the arterial wall is believed to be a critical step in the development of atherosclerosis. MLN1202 targets CCR2 chemokine receptors found on the surface of certain white blood cells including macrophages and monocytes.
Chỉ Định : Investigated for use/treatment in atherosclerosis, cardiovascular disorders, and rheumatoid arthritis.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05486
... loading
... loading