Tìm theo
Mitoxantrone
Các tên gọi khác (4 ) :
  • 1,4-DIHYDROXY-5,8-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)-9,10-anthracenedione
  • Mitoxantrona
  • Mitoxantrone
  • Mitoxantronum
Thuốc chống ung thư và tác động vào hệ thống miễn dịch
Thuốc Gốc
Small Molecule
CAS: 65271-80-9
ĐG : APP Pharmaceuticals , http://www.apppharma.com
CTHH: C22H28N4O6
PTK: 444.4809
An anthracenedione-derived antineoplastic agent. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C22H28N4O6
Phân tử khối
444.4809
Monoisotopic mass
444.200884648
InChI
InChI=1S/C22H28N4O6/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32/h1-4,23-30H,5-12H2
InChI Key
InChIKey=KKZJGLLVHKMTCM-UHFFFAOYSA-N
IUPAC Name
1,4-dihydroxy-5,8-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)-9,10-dihydroanthracene-9,10-dione
Traditional IUPAC Name
mitoxantrone
SMILES
OCCNCCNC1=C2C(=O)C3=C(O)C=CC(O)=C3C(=O)C2=C(NCCNCCO)C=C1
Độ hòa tan
7.34e-01 g/l
logP
-3.1
logS
-2.8
pKa (strongest acidic)
9.78
pKa (Strongest Basic)
9.08
PSA
163.18 Å2
Refractivity
123.53 m3·mol-1
Polarizability
48.49 Å3
Rotatable Bond Count
12
H Bond Acceptor Count
10
H Bond Donor Count
8
Physiological Charge
2
Number of Rings
3
Bioavailability
0
Ghose Filter
true
MDDR-Like Rule
true
Dược Lực Học : Mitoxantrone has been shown in vitro to inhibit B cell, T cell, and macrophage proliferation and impair antigen presentation, as well as the secretion of interferon gamma, TNFa, and IL-2.
Cơ Chế Tác Dụng : An anthracenedione-derived antineoplastic agent. [PubChem] Mitoxantrone, a DNA-reactive agent that intercalates into deoxyribonucleic acid (DNA) through hydrogen bonding, causes crosslinks and strand breaks. Mitoxantrone also interferes with ribonucleic acid (RNA) and is a potent inhibitor of topoisomerase II, an enzyme responsible for uncoiling and repairing damaged DNA. It has a cytocidal effect on both proliferating and nonproliferating cultured human cells, suggesting lack of cell cycle phase specificity.
Dược Động Học :
▧ Absorption :
Poorly absorbed following oral administration
▧ Volume of Distribution :
* 1000 L/m2
▧ Protein binding :
78%
▧ Metabolism :
Hepatic
▧ Half Life :
75 hours
▧ Clearance :
* 21.3 L/hr/m2 [Elderly patients with breast cancer receiving IV administration of 15-90 mg/m2] * 28.3 L/hr/m2 [Non-elderly patients with nasopharyngeal carcinoma receiving IV administration of 15-90 mg/m2] * 16.2 L/hr/m2 [Non-elderly patients with malignant lymphoma receiving IV administration of 15-90 mg/m2]
Độc Tính : Severe leukopenia with infection.
Chỉ Định : For the treatment of secondary (chronic) progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis
Tương Tác Thuốc :
  • Trastuzumab Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Liều Lượng & Cách Dùng : Solution - Intravenous
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Novantrone
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01204
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=4212
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504608
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C11195
ChemSpider
http://www.chemspider.com/Chemical-Structure.4067.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0703-4685-01
PharmGKB
http://www.pharmgkb.org/drug/PA450526
Wikipedia
http://en.wikipedia.org/wiki/Mitoxantrone
RxList
http://www.rxlist.com/cgi/generic2/mitoxantrone.htm
Drugs.com
http://www.drugs.com/cdi/mitoxantrone.html
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