Tìm theo
Mitomycin
Các tên gọi khác (8 ) :
  • 7-Amino-9alpha-methoxymitosane
  • Ametycine
  • Mitamycin
  • Mitocin-C
  • Mitomycin
  • Mitomycin C
  • MMC
  • Mutamycin
Thuốc điều trị ung thư
Thuốc Gốc
Small Molecule
CAS: 50-07-7
ATC: L01DC03
ĐG : Accord Healthcare , http://www.accord-healthcare.com
CTHH: C15H18N4O5
PTK: 334.3272
An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional alkylating agents causing cross-linking of DNA and inhibition of DNA synthesis. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C15H18N4O5
Phân tử khối
334.3272
Monoisotopic mass
334.127719706
InChI
InChI=1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1
InChI Key
InChIKey=NWIBSHFKIJFRCO-WUDYKRTCSA-N
IUPAC Name
[(4S,6S,7R,8S)-11-amino-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.0^{2,7}.0^{4,6}]trideca-1(9),11-dien-8-yl]methyl carbamate
Traditional IUPAC Name
mitomycin
SMILES
CO[C@]12[C@H]3N[C@H]3CN1C1=C([C@H]2COC(N)=O)C(=O)C(N)=C(C)C1=O
Độ tan chảy
>360 °C
Độ sôi
534 °C
Độ hòa tan
Soluble (8430 mg/L)
logP
-0.40
logS
-1.5
pKa (strongest acidic)
-0.3
pKa (Strongest Basic)
6.8
PSA
146.89 Å2
Refractivity
83.27 m3·mol-1
Polarizability
32.77 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
7
H Bond Donor Count
3
Physiological Charge
0
Number of Rings
4
Bioavailability
1
Rule of Five
true
pKa
10.9
Dược Lực Học : Mitomycin is one of the older chemotherapy drugs, which has been around and in use for decades. It is an antibiotic which has been shown to have antitumor activity. Mitomycin selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of mitomycin-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed. Mitomycin has been shown in vitro to inhibit B cell, T cell, and macrophage proliferation and impair antigen presentation, as well as the secretion of interferon gamma, TNFa, and IL-2.
Cơ Chế Tác Dụng : An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional alkylating agents causing cross-linking of DNA and inhibition of DNA synthesis. [PubChem] Mitomycin is activated in vivo to a bifunctional and trifunctional alkylating agent. Binding to DNA leads to cross-linking and inhibition of DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
Dược Động Học :
▧ Absorption :
Erratic.
▧ Metabolism :
Primarily hepatic, some in various other tissues.
▧ Route of Elimination :
Approximately 10% of a dose of mitomycin is excreted unchanged in the urine.
▧ Half Life :
8-48 min
Độc Tính : Oral, mouse: LD50 = 23 mg/kg; Oral, rat: LD50 = 30 mg/kg. Symptoms of overdose include nausea and vomiting.
Chỉ Định : For treatment of malignant neoplasm of lip, oral cavity, pharynx, digestive organs, peritoneum, female breast, and urinary bladder. Also used as an adjunct to ab externo glaucoma surgery.
Tương Tác Thuốc :
  • Trastuzumab Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
  • Vinblastine Potentially severe lung toxicity
  • Vincristine Potentially severe lung toxicity
  • Vindesine Potentially severe lung toxicity
Liều Lượng & Cách Dùng : Injection, powder, lyophilized, for solution - Topical - 0.2 mg/mL
Powder, for solution - Intravesical
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Mitomycin 5 mg vial
    Giá bán buôn : USD >52.43
    Đơn vị tính : vial
  • Biệt dược thương mại : Mutamycin 5 mg vial
    Giá bán buôn : USD >128.75
    Đơn vị tính : vial
  • Biệt dược thương mại : Mitomycin 20 mg vial
    Giá bán buôn : USD >142.55
    Đơn vị tính : vial
  • Biệt dược thương mại : Mitomycin 40 mg vial
    Giá bán buôn : USD >300.0
    Đơn vị tính : vial
  • Biệt dược thương mại : Mutamycin 20 mg vial
    Giá bán buôn : USD >434.8
    Đơn vị tính : vial
  • Biệt dược thương mại : Mutamycin 40 mg vial
    Giá bán buôn : USD >878.48
    Đơn vị tính : vial
Nhà Sản Xuất
  • Sản phẩm biệt dược : Mitosol
  • Công ty :
    Sản phẩm biệt dược : Mitozytrex
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00305
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5746
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508353
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C06681
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00208
ChemSpider
http://www.chemspider.com/Chemical-Structure.5544.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/55390-451-01
PharmGKB
http://www.pharmgkb.org/drug/PA450524
Wikipedia
http://en.wikipedia.org/wiki/Mitomycin
RxList
http://www.rxlist.com/cgi/generic3/mitomycin.htm
Drugs.com
http://www.drugs.com/cdi/mitomycin.html
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