Tìm theo
Mitiglinide
Các tên gọi khác (2) :
  • KAD-1229
  • Mitiglinide calcium hydrate
Insulin và nhóm Thuốc hạ đường huyết
Thuốc Gốc
Small Molecule
CAS: 145375-43-5
ATC: A10BX08
CTHH: C19H25NO3
PTK: 315.4067
Mitiglinide is a drug for the treatment of type 2 diabetes .Mitiglinide is thought to stimulate insulin secretion by closing the ATP-sensitive K(+) (K(ATP)) channels in pancreatic beta-cells.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C19H25NO3
Phân tử khối
315.4067
Monoisotopic mass
315.183443671
InChI
InChI=1S/C19H25NO3/c21-18(20-12-15-8-4-5-9-16(15)13-20)11-17(19(22)23)10-14-6-2-1-3-7-14/h1-3,6-7,15-17H,4-5,8-13H2,(H,22,23)
InChI Key
InChIKey=WPGGHFDDFPHPOB-UHFFFAOYSA-N
IUPAC Name
2-benzyl-4-(octahydro-1H-isoindol-2-yl)-4-oxobutanoic acid
Traditional IUPAC Name
2-benzyl-4-(octahydroisoindol-2-yl)-4-oxobutanoic acid
SMILES
OC(=O)C(CC(=O)N1CC2CCCCC2C1)CC1=CC=CC=C1
Độ hòa tan
7.08e-02 g/l
logP
2.9
logS
-3.6
pKa (strongest acidic)
4.62
pKa (Strongest Basic)
-0.15
PSA
57.61 Å2
Refractivity
88.31 m3·mol-1
Polarizability
35.27 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
3
H Bond Donor Count
1
Physiological Charge
-1
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Mitiglinide belongs to the meglitinide class of blood glucose-lowering drugs. It is approved for use in Japan but has not yet gained FDA approval.
Cơ Chế Tác Dụng : Mitiglinide is a drug for the treatment of type 2 diabetes .Mitiglinide is thought to stimulate insulin secretion by closing the ATP-sensitive K(+) (K(ATP)) channels in pancreatic beta-cells. Mitiglinide is thought to stimulate insulin secretion by binding to and blocking ATP-sensitive K(+) (K(ATP)) channels (Kir6.2/SUR1 complex, KATP channels) in pancreatic beta-cells. Closure of potassium channels causes depolarization which stimulates calcium influx through voltage-gated calcium channels. High intracellular calcium subsequently triggers the exocytosis of insulin granules.
Chỉ Định : For the treatment of type 2 diabetes.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Glufast
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01252
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=3047758
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506527
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01854
ChemSpider
http://www.chemspider.com/Chemical-Structure.2310083.html
PharmGKB
http://www.pharmgkb.org/drug/PA164748124
Wikipedia
http://en.wikipedia.org/wiki/Mitiglinide
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