Tìm theo
Minaprine
Các tên gọi khác (5 ) :
  • 4-(2-((4-Methyl-6-phenyl-3-pyridazinyl)amino)ethyl)morpholine
  • 4-Methyl-3-(2-morpholinoethylamino)-6-phenylpyridazin
  • Minaprina
  • Minaprinum
  • N-(4-Methyl-6-phenyl-3-pyridazinyl)-4-morpholineethanamine
antidepressive agents
Thuốc Gốc
Small Molecule
CAS: 25905-77-5
ATC: N06AX07
CTHH: C17H22N4O
PTK: 298.3828
Minaprine is a psychotropic drug which has proved to be effective in the treatment of various depressive states. Like most antidepressants minaprine antagonizes behavioral despair. Minaprine is an amino-phenylpyridazine antidepressant reported to be relatively free of cardiotoxicity, drowsiness, and weight gain.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C17H22N4O
Phân tử khối
298.3828
Monoisotopic mass
298.179361346
InChI
InChI=1S/C17H22N4O/c1-14-13-16(15-5-3-2-4-6-15)19-20-17(14)18-7-8-21-9-11-22-12-10-21/h2-6,13H,7-12H2,1H3,(H,18,20)
InChI Key
InChIKey=LDMWSLGGVTVJPG-UHFFFAOYSA-N
IUPAC Name
4-methyl-N-[2-(morpholin-4-yl)ethyl]-6-phenylpyridazin-3-amine
Traditional IUPAC Name
minaprine
SMILES
CC1=CC(=NN=C1NCCN1CCOCC1)C1=CC=CC=C1
Độ tan chảy
122 °C
Độ hòa tan
2360 mg/L
logP
2.03
logS
-3.6
pKa (strongest acidic)
19.25
pKa (Strongest Basic)
6.28
PSA
50.28 Å2
Refractivity
91.17 m3·mol-1
Polarizability
33.82 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
5
H Bond Donor Count
1
Physiological Charge
0
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Minaprine is an amino-phenylpyridazine antidepressant reported to be relatively free of cardiotoxicity, drowsiness, and weight gain. Similar to other antidepressant treatments, minaprine attenuates the beta-adrenergic receptor function. Studies have also shown that minaprine improves memory consolidation and that repeated drug administration leads to potentiation of this effect. Moreover, the effects of minaprine on memory consolidation are related to its dopaminergic action.
Cơ Chế Tác Dụng : Minaprine is a psychotropic drug which has proved to be effective in the treatment of various depressive states. Like most antidepressants minaprine antagonizes behavioral despair. Minaprine is an amino-phenylpyridazine antidepressant reported to be relatively free of cardiotoxicity, drowsiness, and weight gain. Minaprine binds to serotonin type 2 receptors and to dopamine D1 and D2 type receptors. It also binds to the serotonin reuptake pump. Therefore, minaprine blocks the reuptake of both dopamine and serotonin. It is also, to a slight degree, cholinomimetic. Thus it may exhibit both mood-brightening and nootropic properties. It also acts as a reversible inhibitor of MAO-A (RIMA).It has also been found to inhibit acetylcholinesterase.
Dược Động Học :

▧ Metabolism :
Hepatic. Cytochrome P4502D is responsible for the 4-hydroxylation of minaprine to 4-hydroxyminaprine.
Chỉ Định : For the treatment of depression
Dữ Kiện Thương Mại
Nhà Sản Xuất
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00805
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=4199
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505380
ChemSpider
http://www.chemspider.com/Chemical-Structure.4054.html
PharmGKB
http://www.pharmgkb.org/drug/PA164748351
... loading
... loading