Tìm theo
Mianserin
Các tên gọi khác (5 ) :
  • 1,2,3,4,10,14b-Hexahydro-2-methyldibenzo(c,F)pyrazino(1,2-a)azepine
  • Mianserina
  • Mianserine
  • Mianserinum
  • Mianseryna
antidepressive agents second generation, serotonin antagonists, histamine h1 antagonists, adrenergic al
Thuốc Gốc
Small Molecule
CAS: 24219-97-4
ATC: N06AX03
CTHH: C18H20N2
PTK: 264.3648
A tetracyclic compound with antidepressant effects. Mianserin was previously available internationally, however in most markets it has been phased out in favor of Mirtazapine.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C18H20N2
Phân tử khối
264.3648
Monoisotopic mass
264.16264865
InChI
InChI=1S/C18H20N2/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19/h2-9,18H,10-13H2,1H3
InChI Key
InChIKey=UEQUQVLFIPOEMF-UHFFFAOYSA-N
IUPAC Name
5-methyl-2,5-diazatetracyclo[13.4.0.0^{2,7}.0^{8,13}]nonadeca-1(15),8(13),9,11,16,18-hexaene
Traditional IUPAC Name
5-methyl-2,5-diazatetracyclo[13.4.0.0^{2,7}.0^{8,13}]nonadeca-1(15),8(13),9,11,16,18-hexaene
SMILES
CN1CCN2C(C1)C1=CC=CC=C1CC1=CC=CC=C21
Độ hòa tan
2.32e-01 g/l
logP
3.83
logS
-3.1
pKa (Strongest Basic)
6.92
PSA
6.48 Å2
Refractivity
84.5 m3·mol-1
Polarizability
30.76 Å3
Rotatable Bond Count
0
H Bond Acceptor Count
2
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
4
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Mianserin is a tetracyclic antidepressant that has antihistaminic and hypnosedative, but almost no anticholinergic, effect. It is a weak inhibitor of norepinephrine reuptake and strongly stimulates the release of norepinephrine. Interactions with serotonin receptors in the central nervous system have also been found. Its effect is usually noticeable after one to three weeks. Mianserin may cause drowsiness and hematological problems.
Cơ Chế Tác Dụng : A tetracyclic compound with antidepressant effects. Mianserin was previously available internationally, however in most markets it has been phased out in favor of Mirtazapine. Mianserin's mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
Dược Động Học :
▧ Absorption :
Absorbed following oral administration.
▧ Protein binding :
90%
▧ Metabolism :
Hepatic.
▧ Half Life :
10-17 hours
Độc Tính : Oral rat LD50: 780mg/kg
Chỉ Định : For the treatment of depression.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Bolvidon
  • Công ty :
    Sản phẩm biệt dược : Depnon
  • Công ty :
    Sản phẩm biệt dược : Lantanon
  • Công ty :
    Sản phẩm biệt dược : Lumin
  • Công ty :
    Sản phẩm biệt dược : Norval
  • Công ty :
    Sản phẩm biệt dược : Tolvon
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB06148
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=4184
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508096
ChemSpider
http://www.chemspider.com/Chemical-Structure.4040.html
PharmGKB
http://www.pharmgkb.org/drug/PA134687937
Wikipedia
http://en.wikipedia.org/wiki/Mianserin
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