Tìm theo
Metixene
Các tên gọi khác (4 ) :
  • Methixen
  • Metisene
  • Metixeno
  • Metixenum
Thuốc Gốc
Small Molecule
CAS: 4969-02-2
ATC: N04AA03
CTHH: C20H23NS
PTK: 309.468
Metixene (or methixene) is a anticholinergic used as an anti-parkinson drug. [Wikipedia]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C20H23NS
Phân tử khối
309.468
Monoisotopic mass
309.155120431
InChI
InChI=1S/C20H23NS/c1-21-12-6-7-15(14-21)13-18-16-8-2-4-10-19(16)22-20-11-5-3-9-17(18)20/h2-5,8-11,15,18H,6-7,12-14H2,1H3
InChI Key
InChIKey=MJFJKKXQDNNUJF-UHFFFAOYSA-N
IUPAC Name
1-methyl-3-(9H-thioxanthen-9-ylmethyl)piperidine
Traditional IUPAC Name
methixene
SMILES
CN1CCCC(CC2C3=CC=CC=C3SC3=CC=CC=C23)C1
Độ tan chảy
< 25 °C
Độ sôi
173 °C at 7.00E-02 mm Hg
Độ hòa tan
Soluble as HCl salt
logP
4.7
logS
-6.5
pKa (Strongest Basic)
9.34
PSA
3.24 Å2
Refractivity
97.17 m3·mol-1
Polarizability
35.67 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
1
H Bond Donor Count
0
Physiological Charge
1
Number of Rings
4
Bioavailability
1
Ghose Filter
true
Dược Lực Học : Metixene is a tertiary antimuscarinic with actions similar to those of atropine; it also has antihistaminic and direct antispasmodic properties. It is used for the symptomatic treatment of parkinsonism, including the alleviation of the extrapyramidal syndrome induced by other drugs such as phenothiazines, but, like other antimuscarinics, it is of no value against tardive dyskinesias. Metixene has been discontinued.
Cơ Chế Tác Dụng : Metixene (or methixene) is a anticholinergic used as an anti-parkinson drug. [Wikipedia] Parkinsonism is thought to result from an imbalance between the excitatory (cholinergic) and inhibitory (dopaminergic) systems in the corpus striatum. The mechanism of action of centrally active anticholinergic drugs such as metixene is considered to relate to competitive antagonism of acetylcholine at muscarinic receptors in the corpus striatum, which then restores the balance.
Dược Động Học :
▧ Absorption :
Absorbed in the gastrointestinal tract following oral administration, however the extent of absorption is not known.
▧ Metabolism :
Hepatic. Metabolism occurs via sulfoxydation and N-demethylation.
Độc Tính : Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures.
Chỉ Định : Used for the symptomatic treatment of parkinsonism.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Cholinfall
  • Công ty :
    Sản phẩm biệt dược : Methixart
  • Công ty :
    Sản phẩm biệt dược : Tremaril
  • Công ty :
    Sản phẩm biệt dược : Tremarit
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00340
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=4167
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508970
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01871
ChemSpider
http://www.chemspider.com/Chemical-Structure.4023.html
PharmGKB
http://www.pharmgkb.org/drug/PA164783811
Wikipedia
http://en.wikipedia.org/wiki/Metixene
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