Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Traditional IUPAC Name
173 °C at 7.00E-02 mm Hg
Độ hòa tan
Soluble as HCl salt
pKa (Strongest Basic)
Dược Lực Học :
Metixene is a tertiary antimuscarinic with actions similar to those of atropine; it also has antihistaminic and direct antispasmodic properties. It is used for the symptomatic treatment of parkinsonism, including the alleviation of the extrapyramidal syndrome induced by other drugs such as phenothiazines, but, like other antimuscarinics, it is of no value against tardive dyskinesias. Metixene has been discontinued.
Cơ Chế Tác Dụng :
Metixene (or methixene) is a anticholinergic used as an anti-parkinson drug. [Wikipedia]
Parkinsonism is thought to result from an imbalance between the excitatory (cholinergic) and inhibitory (dopaminergic) systems in the corpus striatum. The mechanism of action of centrally active anticholinergic drugs such as metixene is considered to relate to competitive antagonism of acetylcholine at muscarinic receptors in the corpus striatum, which then restores the balance.
Dược Động Học :
▧ Absorption :
Absorbed in the gastrointestinal tract following oral administration, however the extent of absorption is not known.
▧ Metabolism :
Hepatic. Metabolism occurs via sulfoxydation and N-demethylation.
Độc Tính :
Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures.
Chỉ Định :
Used for the symptomatic treatment of parkinsonism.
Dữ Kiện Thương Mại
Nhà Sản Xuất
Sản phẩm biệt dược : Cholinfall
Sản phẩm biệt dược : Methixart
Sản phẩm biệt dược : Tremaril
Sản phẩm biệt dược : Tremarit