Tìm theo
Metiamide
Các tên gọi khác (3) :
  • Methiamide
  • Metiamida
  • Metiamidum
anti ulcer agents, histamine h2 antagonists
Thuốc Gốc
Small Molecule
CAS: 34839-70-8
CTHH: C9H16N4S2
PTK: 244.38
Metiamide is a histamine H2-receptor antagonist developed from another H2 antagonist, burimamide. It was an intermediate compound in the development of the successful anti-ulcer drug cimetidine.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C9H16N4S2
Phân tử khối
244.38
Monoisotopic mass
244.081637912
InChI
InChI=1S/C9H16N4S2/c1-7-8(13-6-12-7)5-15-4-3-11-9(14)10-2/h6H,3-5H2,1-2H3,(H,12,13)(H2,10,11,14)
InChI Key
InChIKey=FPBPLBWLMYGIQR-UHFFFAOYSA-N
IUPAC Name
3-methyl-1-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl)thiourea
Traditional IUPAC Name
metiamide
SMILES
CNC(=S)NCCSCC1=C(C)NC=N1
Độ hòa tan
2.87e-02 g/l
logP
0.50
logS
-3.9
pKa (strongest acidic)
12.48
pKa (Strongest Basic)
6.91
PSA
52.74 Å2
Refractivity
70.4 m3·mol-1
Polarizability
27.19 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
1
H Bond Donor Count
3
Physiological Charge
0
Number of Rings
1
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Metiamide is a histamine H2-receptor antagonist. It reduces basal and nocturnal gastric acid secretion and a reduction in gastric volume, acidity, and amount of gastric acid released in response to stimuli including food, caffeine, insulin, betazole, or pentagastrin. Metiamide inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Metiamide include an increase in gastric bacterial flora such as nitrate-reducing organisms.
Cơ Chế Tác Dụng : Metiamide is a histamine H2-receptor antagonist developed from another H2 antagonist, burimamide. It was an intermediate compound in the development of the successful anti-ulcer drug cimetidine. Metiamide binds to an H2-receptor located on the basolateral membrane of the gastric parietal cell, blocking histamine effects. This competitive inhibition results in reduced gastric acid secretion and a reduction in gastric volume and acidity.
Chỉ Định : Potential in the treatment and the management of acid-reflux disorders (GERD), peptic ulcer disease, heartburn, and acid indigestion.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB08805
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07449
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D05004
ChemSpider
http://www.chemspider.com/Chemical-Structure.1265996.html
Wikipedia
http://en.wikipedia.org/wiki/Metiamide
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