Tìm theo
Methyprylon
Các tên gọi khác (9 ) :
  • Methprylon
  • Methyprolon
  • Methyprylon
  • Methyprylone
  • Methyprylonum
  • Metiprilon
  • Metiprilona
  • Metiprilone
  • Noludar
Thuốc an thần
Thuốc Gốc
Small Molecule
CAS: 125-64-4
ATC: N05CE02
CTHH: C10H17NO2
PTK: 183.2475
Methyprylon is a sedative of the piperidinedione derivative family. This medicine was used for treating insomnia, but is now rarely used as it has been replaced by newer drugs with less side effects, such as benzodiazepines. Methyprylon was withdrawn from the US market in June 1965 and the Canadian market in September 1990. [Wikipedia]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C10H17NO2
Phân tử khối
183.2475
Monoisotopic mass
183.125928793
InChI
InChI=1S/C10H17NO2/c1-4-10(5-2)8(12)7(3)6-11-9(10)13/h7H,4-6H2,1-3H3,(H,11,13)
InChI Key
InChIKey=SIDLZWOQUZRBRU-UHFFFAOYSA-N
IUPAC Name
3,3-diethyl-5-methylpiperidine-2,4-dione
Traditional IUPAC Name
dimerin
SMILES
CCC1(CC)C(=O)NCC(C)C1=O
Độ hòa tan
1.15E+004 mg/L
logP
0.78
logS
-1.2
pKa (strongest acidic)
14.53
pKa (Strongest Basic)
-3.1
PSA
46.17 Å2
Refractivity
50.25 m3·mol-1
Polarizability
19.95 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
2
H Bond Donor Count
1
Physiological Charge
0
Number of Rings
1
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Methyprylon, a piperidinedione CNS depressant, is close to barbituric acid in structure, but different enough to be called a "non-barbiturate" sedative-hynotic. Methyprylon is used for insomnia and daytime tension. Methyprylon depresses the activity of muscle tissues, the heart, and the respiratory system.
Cơ Chế Tác Dụng : Methyprylon is a sedative of the piperidinedione derivative family. This medicine was used for treating insomnia, but is now rarely used as it has been replaced by newer drugs with less side effects, such as benzodiazepines. Methyprylon was withdrawn from the US market in June 1965 and the Canadian market in September 1990. [Wikipedia] Methyprylon binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
Dược Động Học :

▧ Protein binding :
60%
▧ Metabolism :
Hepatic. Methyprylon is almost completely metabolized.
▧ Half Life :
6-16 hours
Độc Tính : Symptoms of overdose include excitation and convulsions.
Chỉ Định : For the treatment of insomnia.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Dimerin
  • Công ty :
    Sản phẩm biệt dược : Noctan
  • Công ty :
    Sản phẩm biệt dược : Nodular
  • Công ty :
    Sản phẩm biệt dược : Noludar
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01107
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=4162
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506891
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01150
ChemSpider
http://www.chemspider.com/Chemical-Structure.4018.html
PharmGKB
http://www.pharmgkb.org/drug/PA164746748
Wikipedia
http://en.wikipedia.org/wiki/Methyprylon
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