Tìm theo
Methyltestosterone
Các tên gọi khác (17 ) :
  • 17-beta-Hydroxy-17-methylandrost-4-en-3-one
  • 17-methyltestosterone
  • 17(alpha)-Methyl-delta(4)-androsten-17(beta)-ol-3-one
  • 17alpha-Methyl-3-oxo-4-androsten-17beta-ol
  • 17alpha-Methyl-delta(4)-androsten-17beta-ol-3-one
  • 17alpha-Methyltestosterone
  • 17beta-Hydroxy-17-methylandrost-4-en-3-one
  • 17α-methyl-Δ4-androsten-17β-ol-3-one
  • 17α-methyltestosterone
  • 4-Androstene-17alpha-methyl-17beta-ol-3-one
  • Android
  • Methyltestosterone
  • Methyltestosteronum
  • Metiltestosterona
  • NSC-9701
  • Testred
  • Virilon
Thuốc điều trị ung thư
Thuốc Gốc
Small Molecule
CAS: 58-18-4
CTHH: C20H30O2
PTK: 302.451
A synthetic anabolic steroid used for treating men with testosterone deficiency or similar androgen replacement therapies. Also, has antineoplastic properties and so has been used secondarily in women with advanced breast cancer. Methyltestosterone is a schedule III drug in the US.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C20H30O2
Phân tử khối
302.451
Monoisotopic mass
302.224580204
InChI
InChI=1S/C20H30O2/c1-18-9-6-14(21)12-13(18)4-5-15-16(18)7-10-19(2)17(15)8-11-20(19,3)22/h12,15-17,22H,4-11H2,1-3H3/t15-,16+,17+,18+,19+,20+/m1/s1
InChI Key
InChIKey=GCKMFJBGXUYNAG-HLXURNFRSA-N
IUPAC Name
(1S,2R,10R,11S,14S,15S)-14-hydroxy-2,14,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one
Traditional IUPAC Name
dianabol
SMILES
[H][C@@]12CC[C@](C)(O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C
Độ tan chảy
163 °C
Độ hòa tan
33.9 mg/L (at 25 °C)
logP
3.36
logS
-4.3
pKa (strongest acidic)
19.09
pKa (Strongest Basic)
-0.53
PSA
37.3 Å2
Refractivity
89.07 m3·mol-1
Polarizability
35.65 Å3
Rotatable Bond Count
0
H Bond Acceptor Count
2
H Bond Donor Count
1
Physiological Charge
0
Number of Rings
4
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Testosterone is a steroid hormone from the androgen group. Testosterone is primarily secreted from the testes of males. In females, it is produced in the ovaries, adrenal glands and by conversion of adrostenedione in the periphery. It is the principal male sex hormone and an anabolic steroid. In both males and females, it plays key roles in health and well-being. Examples include enhanced libido, energy, immune function, and protection against osteoporosis. On average, the adult male body produces about twenty times the amount of testosterone than an adult female's body does.
Cơ Chế Tác Dụng : A synthetic anabolic steroid used for treating men with testosterone deficiency or similar androgen replacement therapies. Also, has antineoplastic properties and so has been used secondarily in women with advanced breast cancer. Methyltestosterone is a schedule III drug in the US. The effects of testosterone in humans and other vertebrates occur by way of two main mechanisms: by activation of the androgen receptor (directly or as DHT), and by conversion to estradiol and activation of certain estrogen receptors. Free testosterone (T) is transported into the cytoplasm of target tissue cells, where it can bind to the androgen receptor, or can be reduced to 5α-dihydrotestosterone (DHT) by the cytoplasmic enzyme 5α-reductase. DHT binds to the same androgen receptor even more strongly than T, so that its androgenic potency is about 2.5 times that of T. The T-receptor or DHT-receptor complex undergoes a structural change that allows it to move into the cell nucleus and bind directly to specific nucleotide sequences of the chromosomal DNA. The areas of binding are called hormone response elements (HREs), and influence transcriptional activity of certain genes, producing the androgen effects.
Dược Động Học :
▧ Absorption :
The methyl group aids to increase oral bioavailability.
▧ Protein binding :
40% of testosterone in plasma is bound to sex hormone-binding globulin and 2% remains unbound and the rest is bound to albumin and other proteins.
▧ Metabolism :
Hepatic. Testosterone is metabolized to 17-keto steroids through two different pathways. The major active metabolites are estradiol and dihydrotestosterone (DHT).
▧ Route of Elimination :
90% urine / 10% feces
▧ Half Life :
6-8 hours
Độc Tính : Side effects include amnesia, anxiety, discolored hair, dizziness, dry skin, hirsutism, hostility, impaired urination, paresthesia, penis disorder, peripheral edema, sweating, and vasodilation.
Chỉ Định : Methyltestosterone is an anabolic steroid hormone used to treat men with a testosterone deficiency. It is also used in women to treat breast cancer, breast pain, swelling due to pregnancy, and with the addition of estrogen it can treat symptoms of menopause.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Android
  • Công ty :
    Sản phẩm biệt dược : Methitest
  • Công ty :
    Sản phẩm biệt dược : Testred
  • Công ty :
    Sản phẩm biệt dược : Virilon
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB06710
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07198
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00408
PharmGKB
http://www.pharmgkb.org/drug/PA165958383
Wikipedia
http://en.wikipedia.org/wiki/Methyltestosterone
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