Tìm theo
Methoxyflurane
Các tên gọi khác (7 ) :
  • Methoflurane
  • Methoxyfluoran
  • Methoxyfluran
  • Methoxyfluranum
  • Methyl 1,1-difluoro-2,2-dichloroethyl ether
  • Metoxiflurano
  • Penthrane
anesthetics inhalation
Thuốc Gốc
Small Molecule
CAS: 76-38-0
ATC: N02BG09
ĐG : Medical Development Int Ltd. , http://www.medicaldev.com
CTHH: C3H4Cl2F2O
PTK: 164.966
An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with nitrous oxide to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular relaxation. (From AMA Drug Evaluations Annual, 1994, p180)
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C3H4Cl2F2O
Phân tử khối
164.966
Monoisotopic mass
163.960726574
InChI
InChI=1S/C3H4Cl2F2O/c1-8-3(6,7)2(4)5/h2H,1H3
InChI Key
InChIKey=RFKMCNOHBTXSMU-UHFFFAOYSA-N
IUPAC Name
2,2-dichloro-1,1-difluoro-1-methoxyethane
Traditional IUPAC Name
methoxyflurane
SMILES
COC(F)(F)C(Cl)Cl
Độ tan chảy
-35 °C
Độ sôi
105 °C
Độ hòa tan
2.83E+004 mg/L (at 37 °C)
logP
2.21
logS
-1.4
pKa (Strongest Basic)
-4.5
PSA
9.23 Å2
Refractivity
27.97 m3·mol-1
Polarizability
11.46 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
1
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
0
Bioavailability
1
Rule of Five
true
Dược Lực Học : Methoxyflurane is a general inhalation anesthetic used for induction and maintenance of general anesthesia. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. It does so by decreasing the extent of gap junction mediated cell-cell coupling and altering the activity of the channels that underlie the action potential.
Cơ Chế Tác Dụng : An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with nitrous oxide to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular relaxation. (From AMA Drug Evaluations Annual, 1994, p180) Methoxyflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Methoxyflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Methoxyflurane also binds to the GABA receptor, the large conductance Ca2+ activated potassium channel, the glutamate receptor and the glycine receptor.
Dược Động Học :

▧ Metabolism :
Hepatic.
Độc Tính : LD50=3600 mg/kg (Orally in rats). Symptoms of overexposure include eye irritation, CNS depression, analgesia, anesthesia, seizures, respiratory depression, and liver and kidney damage.
Chỉ Định : For use in the induction and maintenance of general anesthesia
Tương Tác Thuốc :
  • Demeclocycline The tetracycline, demeclocycline, may increase the renal toxicity of methoxyflurane.
  • Minocycline The tetracycline, minocycline, may increase the renal toxicity of methoxyflurane.
  • Phenobarbital The barbiturate, phenobarbital, increases the renal toxicity of methoxyflurane.
  • Primidone The barbiturate, primidone, increases the renal toxicity of methoxyflurane.
  • Tetracycline Tetracycline may increase the renal toxicity of methoxyflurane.
Dữ Kiện Thương Mại
Nhà Sản Xuất
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01028
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=4116
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508879
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07517
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00544
ChemSpider
http://www.chemspider.com/Chemical-Structure.3973.html
PharmGKB
http://www.pharmgkb.org/drug/PA450434
Wikipedia
http://en.wikipedia.org/wiki/Methoxyflurane
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