Tìm theo
Methoxy arachidonyl fluorophosphonate
Các tên gọi khác (1) :
  • MAFP
Thuốc Gốc
Small Molecule
CTHH: C21H36FO2P
PTK: 370.4815
Methoxy arachidonyl fluorophosphonate, commonly referred as MAFP, is an irreversible active site-directed enzyme inhibitor that inhibits nearly all serine hydrolases and serine proteases. It inhibits phospholipase A2 and fatty acid amide hydrolase with special potency, displaying IC50 values in the low-nanomolar range.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C21H36FO2P
Phân tử khối
370.4815
Monoisotopic mass
370.243695113
InChI
InChI=1S/C21H36FO2P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25(22,23)24-2/h7-8,10-11,13-14,16-17H,3-6,9,12,15,18-21H2,1-2H3/b8-7+,11-10+,14-13+,17-16+/t25-/m1/s1
InChI Key
InChIKey=KWKZCGMJGHHOKJ-PDXKBQATSA-N
IUPAC Name
(R)-[(5E,8E,11E,14E)-icosa-5,8,11,14-tetraen-1-yl](methoxy)phosphinoyl fluoride
Traditional IUPAC Name
(R)-(5E,8E,11E,14E)-icosa-5,8,11,14-tetraen-1-yl(methoxy)phosphinoyl fluoride
SMILES
CCCCC\C=C\C\C=C\C\C=C\C\C=C\CCCC[P@@](F)(=O)OC
Độ hòa tan
3.80e-04 g/l
logP
6.83
logS
-6
pKa (Strongest Basic)
-8.5
PSA
26.3 Å2
Refractivity
112.68 m3·mol-1
Polarizability
42.65 Å3
Rotatable Bond Count
16
H Bond Acceptor Count
1
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
0
Bioavailability
0
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB02465
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46936393
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504573
ChemSpider
http://www.chemspider.com/Chemical-Structure.3982.html
Wikipedia
http://en.wikipedia.org/wiki/Mafp
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