Tìm theo
Methoxsalen
Các tên gọi khác (23 ) :
  • 6-Hydroxy-7-methoxy-5-benzofuranacrylic acid delta-lactone
  • 8-Methoxy-[furano-3'.2':6.7-coumarin]
  • 8-Methoxy-2',3',6,7-furocoumarin
  • 8-Methoxy-4',5':6,7-furocoumarin
  • 8-Methoxyfuranocoumarin
  • 8-Methoxypsoralen
  • 8-MOP
  • 8-MP
  • 9-Methoxy-7H-furo[3,2-g][1]benzopyran-7-one
  • Ammoidin
  • Meladinine
  • Meloxine
  • Methoxalen
  • Methoxsalen
  • Méthoxsalène
  • O-Methylxanthotoxol
  • Oxsoralen
  • Ultra mop
  • Uvadex
  • Xanthotoxin
  • Xanthotoxine
  • Xanthoxin
  • Zanthotoxin
Thuốc điều trị bệnh da liễu
Thuốc Gốc
Small Molecule
CAS: 298-81-7
ATC: D05AD02, D05BA02
ĐG : Ben Venue Laboratories Inc. , http://www.benvenue.com
CTHH: C12H8O4
PTK: 216.1895
A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C12H8O4
Phân tử khối
216.1895
Monoisotopic mass
216.042258744
InChI
InChI=1S/C12H8O4/c1-14-12-10-8(4-5-15-10)6-7-2-3-9(13)16-11(7)12/h2-6H,1H3
InChI Key
InChIKey=QXKHYNVANLEOEG-UHFFFAOYSA-N
IUPAC Name
9-methoxy-2H-furo[3,2-g]chromen-2-one
Traditional IUPAC Name
methoxsalen
SMILES
COC1=C2OC(=O)C=CC2=CC2=C1OC=C2
Độ tan chảy
148 °C
Độ hòa tan
47.6 mg/L (at 30 °C)
logP
1.7
logS
-3.66
pKa (Strongest Basic)
-3.5
PSA
48.67 Å2
Refractivity
56.85 m3·mol-1
Polarizability
20.98 Å3
Rotatable Bond Count
1
H Bond Acceptor Count
2
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Methoxsalen selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of Methoxsalen-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.
Cơ Chế Tác Dụng : A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation. [PubChem] After activation it binds preferentially to the guanine and cytosine moieties of DNA, leading to cross-linking of DNA, thus inhibiting DNA synthesis and function.
Dược Động Học :

▧ Route of Elimination :
In both mice and man, methoxsalen is rapidly metabolized. Approximately 95% of the drug is excreted as a series of metabolites in the urine within 24 hours (Pathak et al. 1977).
▧ Half Life :
Approximately 2 hours
Chỉ Định : For the treatment of psoriasis and vitiligo
Tương Tác Thuốc :
  • Ethotoin The hydantoin decreases the effect of psoralene
  • Fosphenytoin The hydantoin decreases the effect of psoralene
  • Mephenytoin The hydantoin decreases the effect of psoralene
  • Phenytoin The hydantoin decreases the effect of psoralene
  • Tacrine The metabolism of Tacrine, a CYP1A2 substrate, may be reduced by strong CYP1A2 inhibitors such as Methoxsalen. Consider modifying therapy to avoid Tacrine toxicity. Monitor the efficacy and toxicity of Tacrine if Methoxsalen is initiated, discontinued or if the dose is changed.
  • Thiothixene The strong CYP1A2 inhibitor, Methoxsalen, may decrease the metabolism and clearance of Thiothixene, a CYP1A2 substrate. Consider alternate therapy or monitor for changes in Thiothixene therapeutic and adverse effects if Methoxsalen is initiated, discontinued or dose changed.
  • Tizanidine Methoxsalen may decrease the metabolism and clearance of Tizanidine. Consider alternate therapy or use caution during co-administration.
Liều Lượng & Cách Dùng : Capsule - Oral
Liquid - Topical
Lotion - Topical
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Delta
    Sản phẩm biệt dược : Deltasoralen
  • Công ty : CLS Pharma
    Sản phẩm biệt dược : Meladinine
  • Công ty : Valeant
    Sản phẩm biệt dược : Oxsoralen
  • Công ty :
    Sản phẩm biệt dược : Oxsoralen-Ultra
  • Công ty : Therakos
    Sản phẩm biệt dược : Uvadex
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00553
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=4114
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506275
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C01864
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00139
ChemSpider
http://www.chemspider.com/Chemical-Structure.3971.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0187-0651-42
PharmGKB
http://www.pharmgkb.org/drug/PA450433
Wikipedia
http://en.wikipedia.org/wiki/Methoxsalen
RxList
http://www.rxlist.com/cgi/generic2/methox.htm
Drugs.com
http://www.drugs.com/cdi/methoxsalen-hard-gelatin-capsules.html
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