Tìm theo
Methocarbamol
Các tên gọi khác (8 ) :
  • (RS)-2-hydroxy-3-(2-methoxyphenoxy)propyl carbamate
  • Delaxin
  • Methocarbamol
  • Méthocarbamol
  • Methocarbamolum
  • Metocarbamol
  • Metocarbamolo
  • Robaxin
Thuốc giãn cơ và tăng trương lực cơ
Thuốc Gốc
Small Molecule
CAS: 532-03-6
ATC: M03BA03
ĐG : Aidarex Pharmacuticals LLC , http://www.aidarex.com
CTHH: C11H15NO5
PTK: 241.2405
A centrally acting muscle relaxant whose mode of action has not been established. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1206)
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C11H15NO5
Phân tử khối
241.2405
Monoisotopic mass
241.095022595
InChI
InChI=1S/C11H15NO5/c1-15-9-4-2-3-5-10(9)16-6-8(13)7-17-11(12)14/h2-5,8,13H,6-7H2,1H3,(H2,12,14)
InChI Key
InChIKey=GNXFOGHNGIVQEH-UHFFFAOYSA-N
IUPAC Name
2-hydroxy-3-(2-methoxyphenoxy)propyl carbamate
Traditional IUPAC Name
methocarbamol
SMILES
COC1=CC=CC=C1OCC(O)COC(N)=O
Độ tan chảy
93 °C
Độ hòa tan
7200 mg/L (at 25 °C)
logP
0.61
logS
-1.8
pKa (strongest acidic)
13.6
pKa (Strongest Basic)
-3.4
PSA
91.01 Å2
Refractivity
59.07 m3·mol-1
Polarizability
24.28 Å3
Rotatable Bond Count
7
H Bond Acceptor Count
4
H Bond Donor Count
2
Physiological Charge
0
Number of Rings
1
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Methocarbamol is a central muscle relaxant for skeletal muscles, used to treat spasms. It is structurally related to guaifenesin. Methocarbamol's exact mechanism of causing skeletal muscle relaxation is unknown. It is thought to work centrally, perhaps by general depressant effects. It has no direct relaxant effects on striated muscle, nerve fibers, or the motor endplate. It will not directly relax contracted skeletal muscles. The drug has a secondary sedative effect.
Cơ Chế Tác Dụng : A centrally acting muscle relaxant whose mode of action has not been established. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1206) The mechanism of action of methocarbamol in humans has not been established, but may be due to central nervous system depression. It has no direct action on the contractile mechanism of striated muscle, the motor end plate or the nerve fiber.
Dược Động Học :
▧ Absorption :
Rapid. Onset of action is about 30 minutes after oral administration.
▧ Metabolism :
Hepatic.
▧ Route of Elimination :
Small amounts of unchanged methocarbamol also are excreted in the urine.
▧ Half Life :
1.14-1.24 hours
▧ Clearance :
* 0.2 – 0.8 L/h/kg [healthy]
Độc Tính : Symptoms of overdose include blurred vision, coma, drowsiness, low blood pressure, nausea, and seizures.
Chỉ Định : For use as an adjunct to rest, physical therapy, and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions.
Tương Tác Thuốc :
  • Triprolidine The CNS depressants, Triprolidine and Methocarbamol, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Liều Lượng & Cách Dùng : Liquid - Intramuscular
Liquid - Intravenous
Tablet - Oral
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Ying Yuan
    Sản phẩm biệt dược : Bolaxin
  • Công ty : Paill
    Sản phẩm biệt dược : Carbaflex
  • Công ty :
    Sản phẩm biệt dược : Delaxin
  • Sản phẩm biệt dược : DoloVisan
  • Công ty : Grape King
    Sản phẩm biệt dược : Fubaxin
  • Công ty : Juvise
    Sản phẩm biệt dược : Lumirelax
  • Công ty : AZ Pharma
    Sản phẩm biệt dược : Metocarbamol
  • Công ty : Labinco
    Sản phẩm biệt dược : Mioflex
  • Công ty : Cheminter
    Sản phẩm biệt dược : Miorel
  • Công ty : Pharmasant
    Sản phẩm biệt dược : Musxan
  • Công ty : Recordati
    Sản phẩm biệt dược : Ortoton
  • Công ty : Winston
    Sản phẩm biệt dược : Rebamol
  • Sản phẩm biệt dược : Robaxin
  • Công ty : Pfizer
    Sản phẩm biệt dược : Robaxin-750
  • Công ty : Khandelwal
    Sản phẩm biệt dược : Robinax
  • Công ty : Armofar
    Sản phẩm biệt dược : Sinaxar
  • Công ty : Honten
    Sản phẩm biệt dược : Taspan
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00423
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=4107
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507761
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00402
ChemSpider
http://www.chemspider.com/Chemical-Structure.3964.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0781-1760-01
PharmGKB
http://www.pharmgkb.org/drug/PA164749506
Wikipedia
http://en.wikipedia.org/wiki/Methocarbamol
RxList
http://www.rxlist.com/cgi/generic/methocar.htm
PDRhealth
http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/rob1384.shtml
Drugs.com
http://www.drugs.com/methocarbamol.html
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