Tìm theo
Methaqualone
Thuốc Gốc
Small Molecule
CAS: 72-44-6
ATC: N05CM01
CTHH: C16H14N2O
PTK: 250.2952
Methaqualone is a sedative-hypnotic drug that is similar in effect to barbiturates, a general central nervous system depressant. The sedative-hypnotic activity was first noted by Indian researchers in the 1950s and in 1962 methaqualone itself was patented in the US by Wallace and Tiernan. Its use peaked in the early 1970s as a hypnotic, for the treatment of insomnia, and as a sedative and muscle relaxant. It has also been used illegally as a recreational drug, commonly known as Quaaludes, Sopors, Ludes or Mandrax (particularly in the 1970s in North America) depending on the manufacturer. Since at least 2001, it has been widely used in South Africa, where it is commonly referred to as "smarties" or "geluk-tablette" (meaning happy tablets). Clandestinely produced methaqualone is still seized by government agencies and police forces around the world. [Wikipedia]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C16H14N2O
Phân tử khối
250.2952
Monoisotopic mass
250.11061308
InChI
InChI=1S/C16H14N2O/c1-11-7-3-6-10-15(11)18-12(2)17-14-9-5-4-8-13(14)16(18)19/h3-10H,1-2H3
InChI Key
InChIKey=JEYCTXHKTXCGPB-UHFFFAOYSA-N
IUPAC Name
2-methyl-3-(2-methylphenyl)-3,4-dihydroquinazolin-4-one
Traditional IUPAC Name
methaqualone
SMILES
CC1=CC=CC=C1N1C(C)=NC2=CC=CC=C2C1=O
Độ tan chảy
120 °C
Độ hòa tan
4.07e-02 g/l
logP
3.17
logS
-3.8
pKa (Strongest Basic)
-1.2
PSA
32.67 Å2
Refractivity
77.11 m3·mol-1
Polarizability
27.32 Å3
Rotatable Bond Count
0
H Bond Acceptor Count
2
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Độc Tính : Symptoms of overdose include delirium, convulsions, muscle spasms or seizure, cardiac arrest, shortness or loss of breath, vomiting or nausea, and coma or death. The LD50 for mice is 1250 mg/kg and for rats is 326 mg/kg (Strasenburg Labs).
Chỉ Định : For the treatment of insomnia, and as a sedative and muscle relaxant.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : Rorer
    Sản phẩm biệt dược : Quaalude
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB04833
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=6292
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507178
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07560
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00557
ChemSpider
http://www.chemspider.com/Chemical-Structure.6055.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089081
Wikipedia
http://en.wikipedia.org/wiki/Methaqualone
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