Tìm theo
Methadyl Acetate
Các tên gọi khác (4 ) :
  • Acetilmetadol
  • Acetylmethadol
  • Acetylmethadolum
  • Betamethadol
Thuốc giảm đau có opioid
Thuốc Gốc
Small Molecule
CAS: 509-74-0
CTHH: C23H31NO2
PTK: 353.4977
A narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C23H31NO2
Phân tử khối
353.4977
Monoisotopic mass
353.235479241
InChI
InChI=1S/C23H31NO2/c1-6-22(26-19(3)25)23(17-18(2)24(4)5,20-13-9-7-10-14-20)21-15-11-8-12-16-21/h7-16,18,22H,6,17H2,1-5H3
InChI Key
InChIKey=XBMIVRRWGCYBTQ-UHFFFAOYSA-N
IUPAC Name
6-(dimethylamino)-4,4-diphenylheptan-3-yl acetate
Traditional IUPAC Name
acetylmethadol
SMILES
CCC(OC(C)=O)C(CC(C)N(C)C)(C1=CC=CC=C1)C1=CC=CC=C1
Độ hòa tan
1.79e-03 g/l
logP
4.27
logS
-5.3
pKa (Strongest Basic)
9.87
PSA
29.54 Å2
Refractivity
117.86 m3·mol-1
Polarizability
40.82 Å3
Rotatable Bond Count
9
H Bond Acceptor Count
2
H Bond Donor Count
0
Physiological Charge
1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Methadyl Acetate is a narcotic analgesic with a long onset and duration of action. The drug decreases a patients opioid use by preventing opioid withdrawal and in how it can mimic some of the effects of opioids.
Cơ Chế Tác Dụng : A narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. [PubChem] Methadyl Acetate is primarily a mu-type opioid receptor agonist. It functions similarily to methadone.
Chỉ Định : Used mainly in the treatment of narcotic dependence.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01433
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=10517
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505532
ChemSpider
http://www.chemspider.com/Chemical-Structure.10080.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50027391
PharmGKB
http://www.pharmgkb.org/drug/PA164746889
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