Tìm theo
Methacholine
Các tên gọi khác (4 ) :
  • Acetyl-beta-methylcholine
  • Acetylmethylcholine
  • MCh
  • Methacholine
Thuốc Gốc
Small Molecule
CAS: 55-92-5
CTHH: C8H18NO2
PTK: 160.234
Methacholine acts as a non-selective muscarinic receptor agonist to stimulate the parasympathetic nervous system. It is most commonly used for diagnosing bronchial hyperreactivity, using the bronchial challenge test. Through this test, the drug causes bronchoconstriction and people with pre-existing airway hyperreactivity, such as asthmatics, will react to lower doses of drug.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C8H18NO2
Phân tử khối
160.234
Monoisotopic mass
160.133753825
InChI
InChI=1S/C8H18NO2/c1-7(11-8(2)10)6-9(3,4)5/h7H,6H2,1-5H3/q+1
InChI Key
InChIKey=NZWOPGCLSHLLPA-UHFFFAOYSA-N
IUPAC Name
[2-(acetyloxy)propyl]trimethylazanium
Traditional IUPAC Name
methacholine
SMILES
CC(C[N+](C)(C)C)OC(C)=O
Độ hòa tan
6.78e-02 g/l
logP
-3.8
logS
-3.5
pKa (Strongest Basic)
-7
PSA
26.3 Å2
Refractivity
55.76 m3·mol-1
Polarizability
18.43 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
1
H Bond Donor Count
0
Physiological Charge
1
Number of Rings
0
Bioavailability
1
Rule of Five
true
Dược Lực Học : Methacholine acts as a non-selective muscarinic receptor agonist to stimulate the parasympathetic nervous system. It is highly active at all of the muscarinic receptors
Cơ Chế Tác Dụng : Methacholine acts as a non-selective muscarinic receptor agonist to stimulate the parasympathetic nervous system. It is most commonly used for diagnosing bronchial hyperreactivity, using the bronchial challenge test. Through this test, the drug causes bronchoconstriction and people with pre-existing airway hyperreactivity, such as asthmatics, will react to lower doses of drug. By agonizing the muscarinic receptors, this drug induces bronchoconstriction. This bronchoconstriction is used as a test in asthmatics and in bronchial hyperreactivity.
Chỉ Định : It is most commonly used for diagnosing bronchial hyperreactivity, using the bronchial challenge test.
Tương Tác Thuốc :
  • Betaxolol Beta-Blockers like betaxolol may worsen brochoconstriction and decrease the effectiveness of agents used to treat the resulting bronchoconstriction. Use of betaxolol and methacholine concomitantly is contraindicated.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Provocholine
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB06709
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=1993
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=99443261
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07471
PharmGKB
http://www.pharmgkb.org/drug/PA165958382
Wikipedia
http://en.wikipedia.org/wiki/Methacholine
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