Tìm theo
Meropenem
Các tên gọi khác (9 ) :
  • (1R,5S,6S)-2-[(3S,5S)-5-DIMETHYLAMINOCARBONYLPYRROLIDIN-3-ylthio]-6-[(R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylic acid
  • (4R,5S,6S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]thio}-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
  • Antibiotic sm 7338
  • Meropenem
  • Meropenem anhydrous
  • Meropenem Hydrate
  • Meropenem trihydrate
  • Meropenemum
  • Meropenemum trihydricum
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 119478-56-7
ATC: J01DH02
ĐG : AstraZeneca Inc. , http://www.astrazeneca.ca
CTHH: C17H25N3O5S
PTK: 383.463
Meropenem is a broad-spectrum carbapenem antibiotic. It is active against Gram-positive and Gram-negative bacteria. Meropenem exerts its action by penetrating bacterial cells readily and interfering with the synthesis of vital cell wall components, which leads to cell death.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C17H25N3O5S
Phân tử khối
383.463
Monoisotopic mass
383.151491615
InChI
InChI=1S/C17H25N3O5S/c1-7-12-11(8(2)21)16(23)20(12)13(17(24)25)14(7)26-9-5-10(18-6-9)15(22)19(3)4/h7-12,18,21H,5-6H2,1-4H3,(H,24,25)/t7-,8-,9+,10+,11-,12-/m1/s1
InChI Key
InChIKey=DMJNNHOOLUXYBV-PQTSNVLCSA-N
IUPAC Name
(4R,5S,6S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
Traditional IUPAC Name
meropenem
SMILES
[H][C@]1([C@@H](C)O)C(=O)N2C(C(O)=O)=C(S[C@@H]3CN[C@@H](C3)C(=O)N(C)C)[C@H](C)[C@]12[H]
Độ hòa tan
Sparingly
logP
-0.6
logS
-1.8
pKa (strongest acidic)
3.47
pKa (Strongest Basic)
9.39
PSA
110.18 Å2
Refractivity
97.89 m3·mol-1
Polarizability
39.29 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
6
H Bond Donor Count
3
Physiological Charge
0
Number of Rings
3
Bioavailability
1
Rule of Five
true
Dược Lực Học : Meropenem is a broad-spectrum carbapenem antibiotic. It is active against Gram-positive and Gram-negative bacteria. Meropenem exerts its action by penetrating bacterial cells readily and interfering with the synthesis of vital cell wall components, which leads to cell death.
Cơ Chế Tác Dụng : Meropenem is a broad-spectrum carbapenem antibiotic. It is active against Gram-positive and Gram-negative bacteria. Meropenem exerts its action by penetrating bacterial cells readily and interfering with the synthesis of vital cell wall components, which leads to cell death. The bactericidal activity of meropenem results from the inhibition of cell wall synthesis. Meropenem readily penetrates the cell wall of most Gram-positive and Gram-negative bacteria to reach penicillin-binding- protein (PBP) targets. Its strongest affinities are toward PBPs 2, 3 and 4 of Escherichia coli and Pseudomonas aeruginosa; and PBPs 1, 2 and 4 of Staphylococcus aureus.
Dược Động Học :

▧ Protein binding :
Approximately 2%.
▧ Metabolism :
Primarily excreted unchanged. There is one metabolite which is microbiologically inactive.
▧ Route of Elimination :
Approximately 70% of the intravenously administered dose is recovered as unchanged meropenem in the urine over 12 hours, after which little further urinary excretion is detectable.
▧ Half Life :
Approximately 1 hour in adults and children 2 years of age and older with normal renal function. Approximately 1.5 hours in children 3 months to 2 years of age.
Độc Tính : In mice and rats, large intravenous doses of meropenem (2200-4000 mg/kg) have been associated with ataxia, dyspnea, convulsions, and mortalities.
Chỉ Định : For use as single agent therapy for the treatment of the following infections when caused by susceptible isolates of the designated microorganisms: complicated skin and skin structure infections due to Staphylococcus aureus (b-lactamase and non-b-lactamase producing, methicillin-susceptible isolates only), Streptococcus pyogenes, Streptococcus agalactiae, viridans group streptococci, Enterococcus faecalis (excluding vancomycin-resistant isolates), Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis, Bacteroides fragilis and Peptostreptococcus species; complicated appendicitis and peritonitis caused by viridans group streptococci, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacteroides fragilis, B. thetaiotaomicron, and Peptostreptococcus species. Also for use in the treatment of bacterial meningitis caused by Streptococcus pneumoniae, Haemophilus influenzae (b-lactamase and non-b-lactamase-producing isolates), and Neisseria meningitidis.
Liều Lượng & Cách Dùng : Powder, for solution - Intravenous
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : ACI
    Sản phẩm biệt dược : Aronem
  • Công ty : Aristopharma
    Sản phẩm biệt dược : Aropen
  • Công ty : Sanofi-Aventis
    Sản phẩm biệt dược : Carbanem
  • Công ty : Lincoln
    Sản phẩm biệt dược : Erope
  • Công ty : Acme
    Sản phẩm biệt dược : Fulspec
  • Công ty : Incepta
    Sản phẩm biệt dược : I-penam
  • Công ty : Admac
    Sản phẩm biệt dược : Merenz
  • Công ty : FHC
    Sản phẩm biệt dược : Merofit
  • Công ty : AstraZeneca
    Sản phẩm biệt dược : Meronem
  • Công ty : Neiss
    Sản phẩm biệt dược : Meronis
  • Sản phẩm biệt dược : Meropen
  • Công ty : Zuventus
    Sản phẩm biệt dược : Merotec
  • Công ty : AstraZeneca
    Sản phẩm biệt dược : Merrem
  • Công ty : AstraZeneca
    Sản phẩm biệt dược : Merrem I.V.
  • Công ty : AstraZeneca
    Sản phẩm biệt dược : Monan
  • Sản phẩm biệt dược : Ropenem
  • Công ty : Sanofi-Aventis
    Sản phẩm biệt dược : Zeropenem
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00760
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D02222
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0310-0325-20
PharmGKB
http://www.pharmgkb.org/drug/PA164764445
Wikipedia
http://en.wikipedia.org/wiki/Meropenem
RxList
http://www.rxlist.com/cgi/generic2/meropen.htm
Drugs.com
http://www.drugs.com/cdi/meropenem.html
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