Tìm theo
Mequitazine
Các tên gọi khác (3) :
  • Kitazemin
  • Mequitazina
  • Mequitazinum
Thuốc chống dị ứng & dùng trong các trường hợp quá mẫn
Thuốc Gốc
Small Molecule
CAS: 29216-28-2
ATC: R06AD07
CTHH: C20H22N2S
PTK: 322.467
Mequitazine is a histamine H1 antagonist (antihistamine). It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C20H22N2S
Phân tử khối
322.467
Monoisotopic mass
322.150369404
InChI
InChI=1S/C20H22N2S/c1-3-7-19-17(5-1)22(18-6-2-4-8-20(18)23-19)14-16-13-21-11-9-15(16)10-12-21/h1-8,15-16H,9-14H2
InChI Key
InChIKey=HOKDBMAJZXIPGC-UHFFFAOYSA-N
IUPAC Name
10-{1-azabicyclo[2.2.2]octan-3-ylmethyl}-10H-phenothiazine
Traditional IUPAC Name
mequitazine
SMILES
C(C1CN2CCC1CC2)N1C2=CC=CC=C2SC2=CC=CC=C12
Độ tan chảy
130.5 °C
Độ hòa tan
4.01e-03 g/l
logP
4.7
logS
-4.9
pKa (Strongest Basic)
8.61
PSA
6.48 Å2
Refractivity
99.05 m3·mol-1
Polarizability
36.25 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
2
H Bond Donor Count
0
Physiological Charge
1
Number of Rings
5
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Mequitazine is a histamine H1 antagonist. It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.
Cơ Chế Tác Dụng : Mequitazine is a histamine H1 antagonist (antihistamine). It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies. Mequitazine binds to the histamine H1 receptor sites on effector cells in the gastrointestinal tract, blood vessels, and respiratory tract. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
Chỉ Định : For the treatment of Hay fever, urticaria (hives) and allergic rhinitis
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Kitazemin
  • Công ty :
    Sản phẩm biệt dược : Metaplexan
  • Công ty :
    Sản phẩm biệt dược : Mircol
  • Công ty :
    Sản phẩm biệt dược : Primalan
  • Công ty :
    Sản phẩm biệt dược : Zesulan
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01071
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=4066
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505779
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C12755
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01324
ChemSpider
http://www.chemspider.com/Chemical-Structure.3926.html
PharmGKB
http://www.pharmgkb.org/drug/PA164748010
Wikipedia
http://en.wikipedia.org/wiki/Mequitazine
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