Tìm theo
Menotropins
fertility agents female, fertility agents
Thuốc Gốc
Biotech
CAS: 61489-71-2
ATC: G03GA02
ĐG : Ferring Pharmaceuticals Inc. , http://www.ferring.com
CTHH: C1014H1609N287O294S27
PTK: 23390.3000
Menotropins contains follicle stimulating hormone (FSH) and luteinizing hormone (LH) purified from the urine of postmenopausal women. It is used as a fertility medication that is injected either subcutaneously or intramuscularly. It is composed of LH with 2 subunits, alpha = 92 residues, beta = 121 residues and FSH with 2 subunits, alpha = 92 residues, beta=111 residues.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C1014H1609N287O294S27
Phân tử khối
23390.3000
Độ tan chảy
55 °C
Độ kỵ nước
-0.063
Điểm đẳng điện tích
8.44
Dược Lực Học : Used to treat female infertility, Menotropins stimulates late follicular maturation and resumption of oocyte meiosis, and initiates rupture of the pre-ovulatory ovarian follicle. Menotropins bind to the LH/hCG/FSH receptor of the granulosa and theca cells of the ovary to effect these changes in the absence of an endogenous LH surge.
Cơ Chế Tác Dụng : Menotropins contains follicle stimulating hormone (FSH) and luteinizing hormone (LH) purified from the urine of postmenopausal women. It is used as a fertility medication that is injected either subcutaneously or intramuscularly. It is composed of LH with 2 subunits, alpha = 92 residues, beta = 121 residues and FSH with 2 subunits, alpha = 92 residues, beta=111 residues. Being a combination drug, Menotropins bind to the Follicle stimulating hormone receptor (which results in ovulation in the absence of sufficient endogenous Luteinizing hormone)and It also binds to the LH receptor, thereby stimulating proper hormone release. The drug contains both FSH and LH,therefore, it induces ovarian follicular growth and development as well as gonadal steroid production in women who do not have ovarian failure.FSH is the primary driver of follicular recruitment and growth in early folliculogenesis, while LH is important for ovarian steroidogenesis and is involved in the physiological events leading to development of a competent pre-ovulatory follicle
Chỉ Định : For the treatment of female infertility
Liều Lượng & Cách Dùng : Powder, for solution - Intramuscular
Powder, for solution - Subcutaneous
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Menopur
  • Công ty :
    Sản phẩm biệt dược : Repronex
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00032
GenBank
http://www.ncbi.nlm.nih.gov/nuccore/X00264
PharmGKB
http://www.pharmgkb.org/drug/PA164749406
Wikipedia
http://en.wikipedia.org/wiki/Menotropins
RxList
http://www.rxlist.com/cgi/generic/menotropins.htm
Drugs.com
http://www.drugs.com/cdi/menotropins.html
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