Tìm theo
Medrysone
Các tên gọi khác (2) :
  • 11beta-Hydroxy-6alpha-methylpregn-4-ene-3,20-dione
  • HMS
anti inflammatory agents
Thuốc Gốc
Small Molecule
CAS: 2668-66-8
ATC: S01BA08
CTHH: C22H32O3
PTK: 344.4877
Medrysone is a corticosteroid used in ophthalmology. [Wikipedia]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C22H32O3
Phân tử khối
344.4877
Monoisotopic mass
344.23514489
InChI
InChI=1S/C22H32O3/c1-12-9-15-17-6-5-16(13(2)23)22(17,4)11-19(25)20(15)21(3)8-7-14(24)10-18(12)21/h10,12,15-17,19-20,25H,5-9,11H2,1-4H3/t12-,15-,16+,17-,19-,20+,21-,22+/m0/s1
InChI Key
InChIKey=GZENKSODFLBBHQ-ILSZZQPISA-N
IUPAC Name
(1S,2R,8S,10S,11S,14S,15S,17S)-14-acetyl-17-hydroxy-2,8,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one
Traditional IUPAC Name
medrysone
SMILES
[H][C@@]12CC[C@H](C(C)=O)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])C[C@H](C)C2=CC(=O)CC[C@]12C
Độ tan chảy
156.5 °C
Độ hòa tan
3.37e-02 g/l
logP
3.2
logS
-4
pKa (strongest acidic)
19.14
pKa (Strongest Basic)
-0.26
PSA
54.37 Å2
Refractivity
98.85 m3·mol-1
Polarizability
39.92 Å3
Rotatable Bond Count
1
H Bond Acceptor Count
3
H Bond Donor Count
1
Physiological Charge
0
Number of Rings
4
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Medrysone is a topical anti-inflammatory corticoidsteroids for ophthalmic use. In patients with increased intraocular pressure and in those susceptible to a rise in intraocular pressure, there is less effect on pressure with medrysone than with dexamethasone or betamethasone. Corticoidsteroids inhibit the edema, fibrin deposition, capillary dilation, and phagocytic migration of the acute inflammatory response, as well as capillary proliferation, deposition of collagen, and scar formation.
Cơ Chế Tác Dụng : Medrysone is a corticosteroid used in ophthalmology. [Wikipedia] There is no generally accepted explanation for the mechanism of action of ocular corticosteroids. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. Initially, the drug binds to the glucocorticoid receptor in the cytosol. This migrates to the nucleus and binds to genetic elements which cause activation and repression of the involved genes in the inflammatory pathway.
Dược Động Học :
▧ Absorption :
Rapidly absorbed following oral administration.
Chỉ Định : For the treatment of allergic conjunctivitis, vernal conjunctivitis, episcleritis, and epinephrine sensitivity.
Liều Lượng & Cách Dùng : Solution / drops - Ophthalmic
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : HMS
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00253
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=247839
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506584
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C14643
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D02289
ChemSpider
http://www.chemspider.com/Chemical-Structure.216968.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/11980-074-05
PharmGKB
http://www.pharmgkb.org/drug/PA450346
Wikipedia
http://en.wikipedia.org/wiki/Medrysone
RxList
http://www.rxlist.com/cgi/generic/medrysoneop.htm
Drugs.com
http://www.drugs.com/mtm/medrysone-ophthalmic.html
... loading
... loading