Tìm theo
Mecasermin
Các tên gọi khác (6 ) :
  • IGF-1
  • IGF1
  • Insulin-like growth factor 1
  • Mecasermin rinfabate
  • Mechano growth factor
  • Somatomedin-C
Thuốc Gốc
Biotech
CAS: 68562-41-4
ATC: H01AC03
ĐG : Baxter International Inc. , http://www.baxter.com
CTHH: C331H518N94O101S7
PTK: 7649.0000
Mecasermin contains recombinant-DNA-engineered human insulin-like growth factor-1 (rhIGF-1). IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges and a molecular weight of 7649 daltons. The amino acid sequence of the product is identical to that of endogenous human IGF-1. The rhIGF-1 protein is synthesized in bacteria (E. coli) that have been modified by the addition of the gene for human IGF-1.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C331H518N94O101S7
Phân tử khối
7649.0000
Dược Lực Học : Mecasermin is a biosynthetic (recombinant DNA origin) form of human insulin growth factor 1 (IGF-1) designed to replace natural IGF-1 in pediatric patients who are deficient, promoting normalized statural growth. Growth hormones (GH) bind to growth hormone receptors (GHR) in the liver and other tissues, which stimulates the synthesis of IGF-1. In target tissues, IGF-1 activates the IGF-1 receptor, resulting in intracellular signals that stimulate growth. Although many actions of the GH are mediated through IGF-1, the precise roles of GH and IGF-1 have not been fully elucidated. Patients with severe primary IGF-1 deficiency (Primary IGFD) fail to produce adequate levels of IGF-1, due to disruption of the GH pathway used to promote IGF-1 release (possible GH pathway disruptions include mutations in the GHR, post-GHR signaling pathway, and IGF-1 gene defects).
Cơ Chế Tác Dụng : Mecasermin contains recombinant-DNA-engineered human insulin-like growth factor-1 (rhIGF-1). IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges and a molecular weight of 7649 daltons. The amino acid sequence of the product is identical to that of endogenous human IGF-1. The rhIGF-1 protein is synthesized in bacteria (E. coli) that have been modified by the addition of the gene for human IGF-1. Mecasermin supplies recombinant-DNA-origin IGF-1, which binds to the Type I IGF-1 receptor. This receptor exerts intra-cellular signaling activity in a number of processes involved in statural growth, including mitogenesis in multiple tissue types, chondrocyte growth and division along cartilage growth plates, and increases in organ growth.
Dược Động Học :
▧ Absorption :
While the bioavailability of rhIGF-1 after subcutaneous administration in healthy subjects has been reported to be close to 100%, the absolute bioavailability of mecasermin given subcutaneously to subjects with primary insulin-like growth factor-1 deficiency (Primary IGFD) has not been determined.
▧ Volume of Distribution :
* 0.257 ± 0.073 L/kg [subjects with severe Primary IGFD]
▧ Protein binding :
In blood, IGF-1 is bound to six IGF binding proteins, with > 80% bound as a complex with IGFBP-3 and an acid-labile subunit.
▧ Metabolism :
Both the liver and the kidney have been shown to metabolize IGF-1.
▧ Route of Elimination :
Both the liver and the kidney have been shown to metabolize IGF-1.
▧ Half Life :
2 hours
Độc Tính : There is no clinical experience with overdosage of mecasermin. Based on known pharmacological effects, acute overdosage would be predicted to lead to hypoglycemia. Long-term overdosage may result in signs and symptoms of acromegaly.
Chỉ Định : For the long-term treatment of growth failure in pediatric patients with Primary IGFD or with GH gene deletion who have developed neutralizing antibodies to GH. It is not indicated to treat Secondary IGFD resulting from GH deficiency, malnutrition, hypothyroidism or other causes; it is not a substitute for GH therapy.
Liều Lượng & Cách Dùng : Solution - Subcutaneous
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Tercica
    Sản phẩm biệt dược : Increlex
  • Công ty :
    Sản phẩm biệt dược : Iplex
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01277
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D04870
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/15054-1040-5
PharmGKB
http://www.pharmgkb.org/drug/PA164774876
RxList
http://www.rxlist.com/cgi/generic/increlex.htm
Drugs.com
http://www.drugs.com/cdi/mecasermin.html
... loading
... loading