Tìm theo
MDX-018
Thuốc Gốc
Small Molecule
MDX-018, also known as HuMax-Inflam, is a fully human antibody that is directed to IL-8 (interleukin-8) and may have potential application in oncology and inflammation. Trials will initially focus on studies to treat glioblastoma, a cancer of the central nervous system. Other possible indications include chronic obstructive pulmonary disease (COPD) and pustular dermatoses. In pre-clinical studies, HuMax-Inflam has been shown to inhibit tumor growth in tumor models using primary human tumors in immunodeficient mice. HuMax-Inflam was also effective in reducing disease activity in palmoplantar pustulosis patients in a clinical study.
Dược Lực Học : MDX-018 is a fully human anti-inflammatory antibody for the treatment of Autoimmune Disease. The drug inhibits tumour growth by targetting interleukin-8 (IL-8), a major inflammation mediator. It reduces disease activity in palmoplantar pustulosis patients and is also effective in the treatment of glioblastoma, which has a very low survival rate.
Cơ Chế Tác Dụng : MDX-018, also known as HuMax-Inflam, is a fully human antibody that is directed to IL-8 (interleukin-8) and may have potential application in oncology and inflammation. Trials will initially focus on studies to treat glioblastoma, a cancer of the central nervous system. Other possible indications include chronic obstructive pulmonary disease (COPD) and pustular dermatoses. In pre-clinical studies, HuMax-Inflam has been shown to inhibit tumor growth in tumor models using primary human tumors in immunodeficient mice. HuMax-Inflam was also effective in reducing disease activity in palmoplantar pustulosis patients in a clinical study. he drug inhibits tumour growth by targetting interleukin-8 (IL-8), a major inflammation mediator.
Chỉ Định : Investigated for use/treatment in autoimmune diseases and inflammatory disorders (unspecified).
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : HuMax-Inflam
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drugbank
http://www.drugbank.ca/drugs/DB05484
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