Tìm theo
Marimastat
Các tên gọi khác (2) :
  • BB-2516
  • Marimastat
enzyme inhibitors
Thuốc Gốc
Small Molecule
CAS: 154039-60-8
CTHH: C15H29N3O5
PTK: 331.4079
Used in the treatment of cancer, Marmiastat is an angiogenesis and metastasis inhibitor. As an angiogenesis inhibitor it limits the growth and production of blood vessels. As an antimetatstatic agent it prevents malignant cells from breaching the basement membranes.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C15H29N3O5
Phân tử khối
331.4079
Monoisotopic mass
331.210721053
InChI
InChI=1S/C15H29N3O5/c1-8(2)7-9(10(19)13(21)18-23)12(20)17-11(14(22)16-6)15(3,4)5/h8-11,19,23H,7H2,1-6H3,(H,16,22)(H,17,20)(H,18,21)/t9-,10+,11-/m1/s1
InChI Key
InChIKey=OCSMOTCMPXTDND-OUAUKWLOSA-N
IUPAC Name
(2S,3R)-N-[(1S)-2,2-dimethyl-1-(methylcarbamoyl)propyl]-N',2-dihydroxy-3-(2-methylpropyl)butanediamide
Traditional IUPAC Name
marimastat
SMILES
CNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)[C@H](O)C(=O)NO)C(C)(C)C
Độ hòa tan
3.38e+00 g/l
logP
0.4
logS
-2
pKa (strongest acidic)
8.61
pKa (Strongest Basic)
-1
PSA
127.76 Å2
Refractivity
84.2 m3·mol-1
Polarizability
34.99 Å3
Rotatable Bond Count
8
H Bond Acceptor Count
5
H Bond Donor Count
5
Physiological Charge
0
Number of Rings
0
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Used in the treatment of cancer, it is an angiogenesis and metastasis inhibitor. As an angiogenesis inhibitor it limits the growth and production of blood vessels. As an antimetatstatic agent it prevents malignant cells from breaching the basement membranes.
Cơ Chế Tác Dụng : Used in the treatment of cancer, Marmiastat is an angiogenesis and metastasis inhibitor. As an angiogenesis inhibitor it limits the growth and production of blood vessels. As an antimetatstatic agent it prevents malignant cells from breaching the basement membranes. Marimastat is a broad spectrum matrix metalloprotease inhibitor. It mimics the peptide structure of natural MMP substrates and binds to matrix metalloproteases, thereby preventing the degradation of the basement membrane by these proteases. This antiprotease action prevents the migration of endothelial cells needed to form new blood vessels. Inhibition of MMPs also prevents the entry and exit of tumor cells into existing blood cells, thereby preventing metastasis.
Chỉ Định : For the treatment of various cancers
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00786
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=119031
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505547
ChemSpider
http://www.chemspider.com/Chemical-Structure.106358.html
PharmGKB
http://www.pharmgkb.org/drug/PA164748329
Wikipedia
http://en.wikipedia.org/wiki/Marimastat
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