Tìm theo
Magnesium Sulfate
Các tên gọi khác (6 ) :
  • Magnesium sulfate (1:1)
  • Magnesium sulfate anhydrous
  • Magnesium sulphate
  • Magnesium(ii) sulfate
  • Magnesiumsulfat
  • MgSO4
Thuốc chống loạn nhịp
Thuốc Gốc
Small Molecule
CAS: 7487-88-9
ATC: A06AD04, A12CC02, B05XA05, D11AX05, V04CC02
ĐG : Denison Pharmaceuticals Inc.
CTHH: MgO4S
PTK: 120.368
A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual, 1992, p1083)
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
MgO4S
Phân tử khối
120.368
Monoisotopic mass
119.936771076
InChI
InChI=1S/Mg.H2O4S/c;1-5(2,3)4/h;(H2,1,2,3,4)/q+2;/p-2
InChI Key
InChIKey=CSNNHWWHGAXBCP-UHFFFAOYSA-L
IUPAC Name
magnesium(2+) ion sulfate
Traditional IUPAC Name
magnesium sulfate
SMILES
[Mg++].[O-]S([O-])(=O)=O
Độ tan chảy
1124 °C (decomposition)
Độ hòa tan
710 mg/mL
logP
-0.91
pKa (strongest acidic)
-3
PSA
80.26 Å2
Refractivity
11.53 m3·mol-1
Polarizability
5.81 Å3
Rotatable Bond Count
0
H Bond Acceptor Count
4
H Bond Donor Count
0
Physiological Charge
-2
Number of Rings
0
Bioavailability
1
Rule of Five
true
Dược Lực Học : Magnesium sulfate is a small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. Magnesium sulfate is gaining popularity as an initial treatment in the management of various dysrhythmias, particularly torsades de pointes, and dyrhythmias secondary to TCA overdose or digitalis toxicity.
Cơ Chế Tác Dụng : A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual, 1992, p1083) Magnesium is the second most plentiful cation of the intracellular fluids. It is essential for the activity of many enzyme systems and plays an important role with regard to neurochemical transmission and muscular excitability. Magnesium sulfate reduces striated muscle contractions and blocks peripheral neuromuscular transmission by reducing acetylcholine release at the myoneural junction. Additionally, Magnesium inhibits Ca2+ influx through dihydropyridine-sensitive, voltage-dependent channels. This accounts for much of its relaxant action on vascular smooth muscle.
Dược Động Học :

▧ Protein binding :
25-30%
▧ Metabolism :
None
▧ Route of Elimination :
Magnesium is excreted solely by the kidney at a rate proportional to the serum concentration and glomerular filtration.
▧ Half Life :
43.2 hours (for newborns)
Độc Tính : LD50 = 1200 mg/kg (rat, subcutaneous). May be harmful if swallowed. May act as an irritant. Adverse reactions include hypotension, ECG changes, diarrhea, urinary retention, CNS depression and respiratory depression.
Chỉ Định : Used for immediate control of life-threatening convulsions in the treatment of severe toxemias (pre-eclampsia and eclampsia) of pregnancy and in the treatment of acute nephritis in children. Also indicated for replacement therapy in magnesium deficiency, especially in acute hypomagnesemia accompanied by signs of tetany similar to those of hypocalcemia. Also used in uterine tetany as a myometriat relaxant.
Tương Tác Thuốc :
  • Atazanavir This gastric pH modifier decreases the levels/effects of atazanavir
  • Dihydrocodeine May enhance CNS depressant effects of CNS depressants. It is recommended to monitor therapy.
  • Eltrombopag Levels of eltrombopag are decreased due to GI inhibition. Separate administration by at least 4 hours.
  • Tiludronate The divalent cation of oral Magnesium sulfate may significantly decrease the absorption of Tiludronate by forming a nonabsorbable chelate. Oral dosing should be separated by at least 2 hours.
  • Triprolidine The CNS depressants, Triprolidine and Magnesium sulfate, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
  • Trovafloxacin Magnesium may decrease the absorption of orally administered Trovafloxacin. Administer Trovafloxacin 2 hours before or 6 hours after a dose of the magnesium containing agent to minimize the interaction.
Liều Lượng & Cách Dùng : Liquid - Intramuscular
Liquid - Intravenous
Liquid - Oral
Pellet - Oral
Powder - Oral
Solution - Intramuscular
Solution - Intravenous
Solution / drops - Oral
Dữ Kiện Thương Mại
Giá thị trường
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00653
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=24083
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508411
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01108
ChemSpider
http://www.chemspider.com/Chemical-Structure.23226.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0409-6729-23
PharmGKB
http://www.pharmgkb.org/drug/PA450302
Wikipedia
http://en.wikipedia.org/wiki/Magnesium_Sulfate
RxList
http://www.rxlist.com/cgi/generic3/mgso4.htm
Drugs.com
http://www.drugs.com/cdi/magnesium-sulfate.html
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